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Review
. 2021 Nov;98(5):943-953.
doi: 10.1111/cbdd.13951. Epub 2021 Sep 19.

Chromones: Privileged scaffold in anticancer drug discovery

Vaishali M Patil  1 , Neeraj Masand  2 , Saroj Verma  3 , Vijay Masand  4
Affiliations
Review

Chromones: Privileged scaffold in anticancer drug discovery

Vaishali M Patil et al. Chem Biol Drug Des. 2021 Nov.

Abstract

In the design and discovery of anticancer drugs, various natural heterocyclic scaffolds have attracted considerable interest as privileged structures. For rational drug design, some of the natural scaffolds such as chromones have exhibited wide acceptability due to their drug-like properties. Among the approved anticancer drugs, the scaffolds with high selectivity for a small group of closely related targets are of importance. In the development of selective anticancer agents, the natural, as well as synthetic, can generate highly selective compounds toward cancer targets. The present manuscript includes more particularly the development of cancer inhibitors incorporating the chromone scaffold, with a strong emphasis on their molecular interactions in the anticancer mechanism. It also includes the structure-activity relationship studies and related examples of lead optimization.

Keywords: anticancer agents; chromones; fused and simple chromone; natural products; privileged scaffolds; synthetic chromone.

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References

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