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. 2021 Sep 14;57(73):9204-9207.
doi: 10.1039/d1cc03537a.

Hydrosilylative reduction of primary amides to primary amines catalyzed by a terminal [Ni-OH] complex

Pragati Pandey  1 , Jitendra K Bera  1
Affiliations

Hydrosilylative reduction of primary amides to primary amines catalyzed by a terminal [Ni-OH] complex

Pragati Pandey et al. Chem Commun (Camb). .

Abstract

A terminal [Ni-OH] complex 1, supported by triflamide-functionalized NHC ligands, catalyzes the hydrosilylative reduction of a range of primary amides into primary amines in good to excellent yields under base-free conditions with key functional group tolerance. Catalyst 1 is also effective for the reduction of a variety of tertiary and secondary amides. In contrast to literature reports, the reactivity of 1 towards amide reduction follows an inverse trend, i.e., 1° amide > 3° amide > 2° amide. The reaction does not follow a usual dehydration pathway.

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