Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Nov;18(11):e2100663.
doi: 10.1002/cbdv.202100663. Epub 2021 Sep 29.

Azaphilones and Meroterpenoids from the Soft Coral-Derived Fungus Penicillium glabrum glmu003

Han Zhang  1 , Xin-Xin Lei  1 , Surun Shao  1 , Xuefeng Zhou  2   3 , Yunqiu Li  1 , Bin Yang  2   3
Affiliations

Azaphilones and Meroterpenoids from the Soft Coral-Derived Fungus Penicillium glabrum glmu003

Han Zhang et al. Chem Biodivers. 2021 Nov.

Abstract

Two new azaphilone compounds, daldinins G (1) and H (2), together with nine known compounds daldinin D (3), sargassopenilline B (4), austalide V (5), austalide K (6), austalide P (7), austalide P acid (8), austalide H (9), 13-O-deacetyaustalide I (10), and 17-O-demethylaustalide B (11), were isolated from the soft coral-derived fungus Penicillium glabrum glmu003. The new structures of 1 and 2 were elucidated on the basis of 1D and 2D NMR, mass spectra, and electronic circular dichroism (ECD) data analysis. Compound 5 showed weak inhibitory activity against pancreatic lipase (PL) with IC50 value of 23.9 μg/mL.

Keywords: PL inhibitory; Penicillium glabrum; azaphilone; meroterpenoid.

PubMed Disclaimer

References

    1. J. Bao, J. Wang, X.-Y. Zhang, X.-H. Nong, S.-H. Qi, ‘New furanone derivatives and alkaloids from the co-culture of marine-derived fungi Aspergillus sclerotiorum and Penicillium citrinum’, Chem. Biodiversity 2017, 14.
    1. M. Chen, L. Han, C.-L. Shao, Z.-G. She, C.-Y. Wang, ‘Bioactive diphenyl ether derivatives from a Gorgonian-derived fungus Talaromyces sp.’, Chem. Biodiversity 2015, 12, 443-450.
    1. W. Yang, Y. Chen, R. Cai, G. Zou, B. Wang, Z. She, ‘Benzopyran derivatives and an aliphatic compound from a mangrove endophytic fungus Penicillium citrinum QJF-22’, Chem. Biodiversity 2020, 17.
    1. O. I. Zhuravleva, M. P. Sobolevskaya, S. S. Afiyatullov, N. N. Kirichuk, V. A. Denisenko, P. S. Dmitrenok, E. A. Yurchenko, S. A. Dyshlovoy, ‘Sargassopenillines A−G, 6,6-Spiroketals from the alga-derived fungi Penicillium thomii and Penicillium lividum’, Mar. Drugs 2014, 12, 5930-5943.
    1. C. Chen, H. Tao, W. Chen, B. Yang, X. Zhou, X. Luo, Y. Liu, ‘Recent advances in the chemistry and biology of azaphilones’, RSC Adv. 2020, 10, 10197-10220.

MeSH terms

Supplementary concepts

LinkOut - more resources