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. 2021 Sep 1;4(9):e2126344.
doi: 10.1001/jamanetworkopen.2021.26344.

Safety and Antibody Response After 1 and 2 Doses of BNT162b2 mRNA Vaccine in Recipients of Allogeneic Hematopoietic Stem Cell Transplant

Affiliations

Safety and Antibody Response After 1 and 2 Doses of BNT162b2 mRNA Vaccine in Recipients of Allogeneic Hematopoietic Stem Cell Transplant

Amandine Le Bourgeois et al. JAMA Netw Open. .

Abstract

This cohort study examines safety and antibody responses after 1 and 2 doses of BNT162b2 mRNA vaccine in recipients of allogeneic hematopoietic stem cell transplant (HSCT).

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Chevallier reported receiving honoraria from Pfizer outside the submitted work. No other disclosures were reported.

Figures

Figure.
Figure.. Anti–SARS-CoV-2 Titers After the First and Second Vaccine Injections
Box plots show anti–SARS-CoV-2 spike protein receptor titers after the first and the second vaccine injections. Lines within boxes denote medians, error bars denote 95% CIs, circles denote data for individual patients. Comparisons are between patients for whom follow-up after allogeneic hematopoietic stem cell transplant was less than 1 year vs between 1 and 2 years vs more than 2 years.

Comment in

References

    1. García-Suárez J, de la Cruz J, Cedillo Á, et al. ; Asociación Madrileña de Hematología y Hemoterapia (AMHH) . Impact of hematologic malignancy and type of cancer therapy on COVID-19 severity and mortality: lessons from a large population-based registry study. J Hematol Oncol. 2020;13(1):133. doi:10.1186/s13045-020-00970-7 - DOI - PMC - PubMed
    1. Xhaard A, Xhaard C, D’Aveni M, et al. . Risk factors for a severe form of COVID-19 after allogeneic haematopoietic stem cell transplantation: a Société Francophone de Greffe de Moelle et de Thérapie cellulaire (SFGM-TC) multicentre cohort study. Br J Haematol. 2021;192(5):e121-e124. doi:10.1111/bjh.17260 - DOI - PMC - PubMed
    1. Walsh EE, Frenck RW Jr, Falsey AR, et al. . Safety and immunogenicity of two RNA-based Covid-19 vaccine candidates. N Engl J Med. 2020;383(25):2439-2450. doi:10.1056/NEJMoa2027906 - DOI - PMC - PubMed
    1. Chevallier P, Coste-Burel M, Le Bourgeois A, et al. . Safety and immunogenicity of a first dose of SARS-CoV-2 mRNA vaccine in allogeneic hematopoietic stem-cells recipients. EJHaem. Published online June 1, 2021. doi:10.1002/jha2.242 - DOI - PMC - PubMed
    1. Boyarsky BJ, Werbel WA, Avery RK, et al. . Antibody response to 2-dose SARS-CoV-2 mRNA vaccine series in solid organ transplant recipients. JAMA. 2021;325(21):2204-2206. doi:10.1001/jama.2021.7489 - DOI - PMC - PubMed