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Comment
. 2021 Sep 13;39(9):1175-1177.
doi: 10.1016/j.ccell.2021.07.022.

Two opposing sub-populations of fibroblasts decide progression of pancreatic cancer

Emily J Kay  1 , Sara Zanivan  2
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Free article
Comment

Two opposing sub-populations of fibroblasts decide progression of pancreatic cancer

Emily J Kay et al. Cancer Cell. .
Free article

Abstract

Fibroblasts are a major non-neoplastic component of solid tumors, yet it is unclear whether they promote or oppose cancer. In this issue of Cancer Cell, Hutton et al. report two distinct fibroblast subpopulations that are defined by a single marker, one subpopulation that is tumor permissive and the other that is tumor suppressive and supports anti-tumor immunity.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity.
    Hutton C, Heider F, Blanco-Gomez A, Banyard A, Kononov A, Zhang X, Karim S, Paulus-Hock V, Watt D, Steele N, Kemp S, Hogg EKJ, Kelly J, Jackstadt RF, Lopes F, Menotti M, Chisholm L, Lamarca A, Valle J, Sansom OJ, Springer C, Malliri A, Marais R, Pasca di Magliano M, Zelenay S, Morton JP, Jørgensen C. Hutton C, et al. Cancer Cell. 2021 Sep 13;39(9):1227-1244.e20. doi: 10.1016/j.ccell.2021.06.017. Epub 2021 Jul 22. Cancer Cell. 2021. PMID: 34297917 Free PMC article.

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