Diversity in chromosome numbers promotes resistance to chemotherapeutics
- PMID: 34520761
- DOI: 10.1016/j.devcel.2021.08.017
Diversity in chromosome numbers promotes resistance to chemotherapeutics
Abstract
In this issue of Developmental Cell, papers from Ippolito et al. and from Lukow et al. show that increasing the range of aneuploidy states in cells increases their chance of developing resistance when they are subjected to chemotherapy.
Crown Copyright © 2021. Published by Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
Comment on
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Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies.Dev Cell. 2021 Sep 13;56(17):2427-2439.e4. doi: 10.1016/j.devcel.2021.07.009. Epub 2021 Aug 4. Dev Cell. 2021. PMID: 34352222 Free PMC article.
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Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy.Dev Cell. 2021 Sep 13;56(17):2440-2454.e6. doi: 10.1016/j.devcel.2021.07.006. Epub 2021 Aug 4. Dev Cell. 2021. PMID: 34352223
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