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Comment
. 2021 Nov;22(11):689.
doi: 10.1038/s41576-021-00420-1.

A body-wide view of somatic mutations

Darren J Burgess  1
Affiliations
Comment

A body-wide view of somatic mutations

Darren J Burgess. Nat Rev Genet. 2021 Nov.
No abstract available

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Comment on

  • The mutational landscape of human somatic and germline cells.
    Moore L, Cagan A, Coorens THH, Neville MDC, Sanghvi R, Sanders MA, Oliver TRW, Leongamornlert D, Ellis P, Noorani A, Mitchell TJ, Butler TM, Hooks Y, Warren AY, Jorgensen M, Dawson KJ, Menzies A, O'Neill L, Latimer C, Teng M, van Boxtel R, Iacobuzio-Donahue CA, Martincorena I, Heer R, Campbell PJ, Fitzgerald RC, Stratton MR, Rahbari R. Moore L, et al. Nature. 2021 Sep;597(7876):381-386. doi: 10.1038/s41586-021-03822-7. Epub 2021 Aug 25. Nature. 2021. PMID: 34433962
  • Extensive phylogenies of human development inferred from somatic mutations.
    Coorens THH, Moore L, Robinson PS, Sanghvi R, Christopher J, Hewinson J, Przybilla MJ, Lawson ARJ, Spencer Chapman M, Cagan A, Oliver TRW, Neville MDC, Hooks Y, Noorani A, Mitchell TJ, Fitzgerald RC, Campbell PJ, Martincorena I, Rahbari R, Stratton MR. Coorens THH, et al. Nature. 2021 Sep;597(7876):387-392. doi: 10.1038/s41586-021-03790-y. Epub 2021 Aug 25. Nature. 2021. PMID: 34433963
  • A body map of somatic mutagenesis in morphologically normal human tissues.
    Li R, Di L, Li J, Fan W, Liu Y, Guo W, Liu W, Liu L, Li Q, Chen L, Chen Y, Miao C, Liu H, Wang Y, Ma Y, Xu D, Lin D, Huang Y, Wang J, Bai F, Wu C. Li R, et al. Nature. 2021 Sep;597(7876):398-403. doi: 10.1038/s41586-021-03836-1. Epub 2021 Aug 25. Nature. 2021. PMID: 34433965
  • Clonal dynamics in early human embryogenesis inferred from somatic mutation.
    Park S, Mali NM, Kim R, Choi JW, Lee J, Lim J, Park JM, Park JW, Kim D, Kim T, Yi K, Choi JH, Kwon SG, Hong JH, Youk J, An Y, Kim SY, Oh SA, Kwon Y, Hong D, Kim M, Kim DS, Park JY, Oh JW, Ju YS. Park S, et al. Nature. 2021 Sep;597(7876):393-397. doi: 10.1038/s41586-021-03786-8. Epub 2021 Aug 25. Nature. 2021. PMID: 34433967

References

Original articles
    1. Park, S. et al. Clonal dynamics in early human embryogenesis inferred from somatic mutation. Nature https://doi.org/10.1038/s41586-021-03786-8 (2021) - DOI - PubMed - PMC
    1. Coorens, T. H. H. et al. Extensive phylogenies of human development inferred from somatic mutations. Nature https://doi.org/10.1038/s41586-021-03790-y (2021) - DOI - PubMed - PMC
    1. Moore, L. et al. The mutational landscape of human somatic and germline cells. Nature https://doi.org/10.1038/s41586-021-03822-7 (2021) - DOI - PubMed - PMC
    1. Li, R. et al. A body map of somatic mutagenesis in morphologically normal human tissues. Nature https://doi.org/10.1038/s41586-021-03836-1 (2021) - DOI - PubMed - PMC

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