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. 2021 Aug 21:16:65-68.
doi: 10.1016/j.jdcr.2021.08.016. eCollection 2021 Oct.

Reflectance confocal findings in a large-cell acanthoma with histologic correlation

Alli J Blumstein  1 , Katharine L Hanlon  2   3 , Wei-Shen Chen  3 , George Elgart  4 , James M Grichnik  2   3 , Lilia Correa-Selm  2   3
Affiliations

Reflectance confocal findings in a large-cell acanthoma with histologic correlation

Alli J Blumstein et al. JAAD Case Rep. .
No abstract available

Keywords: LCA, large-cell acanthoma; RCM, reflectance confocal microscope; confocal microscopy; dermoscopy; histology correlation; large-cell acanthoma; lentigo; lentigo maligna.

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Conflict of interest statement

Dr Grichnik serves as a consultant for Galileo Group, Canfield Scientific and has previously received equipment and meeting support from Caliber Imaging and Diagnostics. Dr Correa-Selm served as speaker of Accutec Blades and was a consultant for Castle Biosciences. Authors Blumstein and Hanlon and Drs Chen and Elgart have no conflicts of interest to declare.

Figures

Fig 1
Fig 1
A, Clinical photograph and (B) dermoscopic image of large-cell acanthoma showing nonuniform shape with equivocal dermoscopic characteristics.
Fig 2
Fig 2
Reflectance confocal microscopy of large-cell acanthoma (at the low-power view) showing a broadened honeycomb pattern (A), nonedged and partially edged dermal papillae and highly refractile dendritic cells in sheets (arrow), and atypical cobblestone pattern with cells of different sizes and visible nuclei (B).
Fig 3
Fig 3
A, Histopathology of large-cell acanthoma, at low power, illustrates the solar elastosis and a relatively flattened junction. B, The hematoxylin-eosin–stained section, at high power, shows enlarged nuclei of keratinocytes, corresponding to the cellular findings of reflectance confocal microscopy. C, At high power, Mart1 stain shows nonconfluent, basally oriented junctional melanocytes. D, CD1a immunostaining reveals abundant intraepidermal Langerhans cells. (A and B, Hematoxylin-eosin stain; C, Mart1 stain; D, CD1a stain.)
See this image and copyright information in PMC

References

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