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Case Reports
. 2021 Aug 18:16:69-71.
doi: 10.1016/j.jdcr.2021.07.036. eCollection 2021 Oct.

Epidermolysis bullosa pruriginosa responding to dupilumab

Rebecca C Clawson  1 , Stephan F Duran  1 , Robert J Pariser  1   2
Affiliations
Case Reports

Epidermolysis bullosa pruriginosa responding to dupilumab

Rebecca C Clawson et al. JAAD Case Rep. .
No abstract available

Keywords: EB, epidermolysis bullosa; EBP, epidermolysis bullosa pruriginosa; IL, interleukin; dupilumab; epidermolysis bullosa pruriginosa; pruritus.

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Conflict of interest statement

None disclosed.

Figures

Fig 1
Fig 1
Coalescing pink papulonodular lesions on the extensor surfaces of the left lower extremity. This image was taken on initial presentation, shortly before a biopsy was obtained from a similar lesion on the dorsum of the right foot.
Fig 2
Fig 2
Hematoxylin-eosin–stained biopsies taken from the patient's lower extremity. These photomicrographs reveal (A) a scale-crust overlying verrucous acanthosis and (B) focal dermoepidermal separation.
Fig 3
Fig 3
Improvement of pruriginous lesions following 6 months of dupilumab injections every 2 weeks.
See this image and copyright information in PMC

References

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    1. Cambiaghi S., Brusasco A., Restano L., Cavalli R., Tadini G. Epidermolysis bullosa pruriginosa. Dermatology. 1997;195(1):65–68. doi: 10.1159/000245691. - DOI - PubMed
    1. Al-Maani N.W.S. King's College London (University of London); 2017. Refining Genotype-Phenotype Correlation in Epidermolysis Bullosa. Dissertation.
    1. Banky J.P., Sheridan A.T., Storer E.L., Marshman G. Successful treatment of epidermolysis bullosa pruriginosa with topical tacrolimus. Arch Dermatol. 2004;140(7):794–796. doi: 10.1001/archderm.140.7.794. - DOI - PubMed
    1. Das J.K., Sengupta S., Gangopadhyay A.K. Epidermolysis bullosa pruriginosa - report of three cases. Indian J Dermatol Venereol Leprol. 2005;71(2):109–111. doi: 10.4103/0378-6323.13996. - DOI - PubMed

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