Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Sep 15;50(1):68-73.
doi: 10.1515/jpm-2020-0580. Print 2022 Jan 27.

Perinatal outcomes in pregnancies complicated by acute pancreatitis

Emmy Cai  1 , Nicholas Czuzoj-Shulman  2 , Haim A Abenhaim  1   2
Affiliations

Perinatal outcomes in pregnancies complicated by acute pancreatitis

Emmy Cai et al. J Perinat Med. .

Abstract

Objectives: Acute pancreatitis is a rare condition that can be associated with significant complications. The objective of this study is to evaluate the maternal and newborn outcomes associated with acute pancreatitis in pregnancy.

Methods: A retrospective cohort study using the Healthcare Cost and Utilization Project-Nationwide Inpatient Sample from the United States was performed. All pregnant patients with acute pancreatitis were identified using International Classification of Disease-9 coding from 1999 to 2015. The effect of acute pancreatitis on maternal and neonatal outcomes in pregnancy was evaluated using multivariate logistic regression, while adjusting for baseline maternal characteristics.

Results: From 1999 to 2015, there were a total of 13,815,919 women who gave birth. There were a total of 14,258 admissions of women diagnosed with acute pancreatitis, including 1,756 who delivered during their admission and 12,502 women who were admitted in the antepartum period and did not deliver during the same admission. Acute pancreatitis was associated with increased risk of prematurity, OR 3.78 (95% CI 3.38-4.22), preeclampsia, 3.81(3.33-4.36), postpartum hemorrhage, 1.90(1.55-2.33), maternal death, 9.15(6.05-13.85), and fetal demise, 2.60(1.86-3.62) among women diagnosed with acute pancreatitis. Among women with acute pancreatitis, delivery was associated with increased risk of requiring transfusions, 6.06(4.87-7.54), developing venous thromboembolisms, 2.77(1.83-4.18), acute respiratory failure, 3.66(2.73-4.91), and disseminated intravascular coagulation, 8.12(4.12-16.03).

Conclusions: Acute pancreatitis in pregnancy is associated with severe complications, such as maternal and fetal death. Understanding the risk factors that may lead to these complications can help prevent or minimize them through close fetal and maternal monitoring.

Keywords: acute pancreatitis; maternal outcomes; neonatal outcomes; pancreatitis.

PubMed Disclaimer

References

    1. Pandey, R, Jacob, A, Brooks, H. Acute pancreatitis in pregnancy: review of three cases and anaesthetic management. Int J Obstet Anesth 2012;21:360–3. https://doi.org/10.1016/j.ijoa.2012.07.004.
    1. Ducarme, G, Maire, F, Chatel, P, Luton, D, Hammel, P. Acute pancreatitis during pregnancy: a review. J Perinatol 2014;34:87–94. https://doi.org/10.1038/jp.2013.161.
    1. Stimac, D, Stimac, T. Acute pancreatitis during pregnancy. Eur J Gastroenterol Hepatol 2011;23:839–44. https://doi.org/10.1097/meg.0b013e328349b199.
    1. Tang, SJ, Rodriguez-Frias, E, Singh, S, Mayo, MJ, Jazrawi, SF, Sreenarasimhaiah, J, et al.. Acute pancreatitis during pregnancy. Clin Gastroenterol Hepatol 2010;8:85–90. https://doi.org/10.1016/j.cgh.2009.08.035.
    1. Jin, J, Yu, YH, Zhong, M, Zhang, GW. Analyzing and identifying risk factors for acute pancreatitis with different etiologies in pregnancy. J Matern Fetal Neonatal Med 2015;28:267–71. https://doi.org/10.3109/14767058.2014.913132.

LinkOut - more resources