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Review
. 2022 Nov;29(11):3100-3105.
doi: 10.1007/s43032-021-00740-x. Epub 2021 Sep 15.

Intrahepatic Cholestasis of Pregnancy: Toward Improving Perinatal Outcome

Antonio F Saad  1   2 , Luis D Pacheco  3   4 , Lucy Chappell  5 , George R Saade  3
Affiliations
Review

Intrahepatic Cholestasis of Pregnancy: Toward Improving Perinatal Outcome

Antonio F Saad et al. Reprod Sci. 2022 Nov.

Abstract

Intrahepatic cholestasis of pregnancy (ICP) is associated with poor perinatal outcomes in some women such as preterm delivery and fetal demise. Ursodeoxycholic acid (UDCA) is the main therapeutic agent for ICP, but recent evidence failed to show an impact on most perinatal outcomes. Our objective is to summarize the latest evidence in the management of ICP, with a focus on perinatal outcome. We propose a practical approach that combines pharmacotherapy with biochemical and fetal testing, as well as delivery planning.

Keywords: Bile acid; Cholestasis; Hepatic disease; Pregnancy.

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References

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