Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Nov 25;385(22):2103-2105.
doi: 10.1056/NEJMc2112974. Epub 2021 Sep 15.

Vaccine-Induced Thrombocytopenia with Severe Headache

Affiliations

Vaccine-Induced Thrombocytopenia with Severe Headache

Farid Salih et al. N Engl J Med. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1. Clinical and Laboratory Data for Patients with VIT and Severe Headache (Pre-VITT Syndrome).
Shown are the time courses of the manifestation of pre-VITT syndrome (defined by headache onset), hospital admission (including emergency department admission and discharge in Patients 1 and 2), platelet counts, and cerebrovascular complications (in Patients 1, 2, and 3), as well as medical and neurosurgical treatment (decompressive craniectomy). In each graph, the number of days since the onset of headache is shown on the x axis and platelet counts on the y axis. Outcomes were assessed with the modified Rankin scale (mRS); scores on the scale range from 0 to 6, with higher scores indicating greater disability (0 indicates no symptoms, and 6 indicates death). CVST denotes cerebral venous sinus thrombosis, VIT vaccine-induced thrombocytopenia, and VITT vaccine-induced immune thrombotic thrombocytopenia.

References

    1. Long B, Bridwell R, Gottlieb M. Thrombosis with thrombocytopenia syndrome associated with COVID-19 vaccines. Am J Emerg Med 2021;49:58-61. - PMC - PubMed
    1. Greinacher A, Thiele T, Warkentin TE, Weisser K, Kyrle PA, Eichinger S. Thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination. N Engl J Med 2021;384:2092-2101. - PMC - PubMed
    1. Scully M, Singh D, Lown R, et al. Pathologic antibodies to platelet factor 4 after ChAdOx1 nCoV-19 vaccination. N Engl J Med 2021;384:2202-2211. - PMC - PubMed
    1. Bussel JB, Connors JM, Cines DB, et al. Thrombosis with thrombocytopenia syndrome (also termed vaccine-induced thrombotic thrombocytopenia), version 1.6. American Society of Hematology, August 12, 2021. (https://www.hematology.org/covid-19/vaccine-induced-immune-thrombotic-th...).
    1. Bourguignon A, Arnold DM, Warkentin TE, et al. Adjunct immune globulin for vaccine-induced thrombotic thrombocytopenia. N Engl J Med 2021;385:720-728. - PMC - PubMed

MeSH terms