In matters of the heart, (cellular) communication is key

Federico F De Ponti¹, Charlotte L Scott²

Affiliations

¹ Laboratory of Myeloid Cell Biology in Tissue Damage and Inflammation, VIB Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Faculty of Sciences, Ghent University, Ghent, Belgium.
² Laboratory of Myeloid Cell Biology in Tissue Damage and Inflammation, VIB Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Faculty of Sciences, Ghent University, Ghent, Belgium; Department of Chemical Sciences, Bernal Institute, University of Limerick, Castletroy, Co. Limerick, Ireland. Electronic address: charlotte.scott@ugent.be.

PMID: 34525333
DOI: 10.1016/j.immuni.2021.08.004

Free article

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In matters of the heart, (cellular) communication is key

Federico F De Ponti et al. Immunity. 2021.

Free article

. 2021 Sep 14;54(9):1906-1908.

doi: 10.1016/j.immuni.2021.08.004.

Authors

Federico F De Ponti¹, Charlotte L Scott²

Affiliations

¹ Laboratory of Myeloid Cell Biology in Tissue Damage and Inflammation, VIB Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Faculty of Sciences, Ghent University, Ghent, Belgium.
² Laboratory of Myeloid Cell Biology in Tissue Damage and Inflammation, VIB Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Faculty of Sciences, Ghent University, Ghent, Belgium; Department of Chemical Sciences, Bernal Institute, University of Limerick, Castletroy, Co. Limerick, Ireland. Electronic address: charlotte.scott@ugent.be.

PMID: 34525333
DOI: 10.1016/j.immuni.2021.08.004

Abstract

To maintain cardiac output, the failing heart undergoes significant remodeling. However, the mechanisms regulating this remain unclear. In this issue of Immunity, Zaman et al. and Wong, Mohan, and Kopecky et al. uncover an interaction between resident cardiac macrophages and cardiomyocytes governing this process.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

Resident cardiac macrophages mediate adaptive myocardial remodeling.
Wong NR, Mohan J, Kopecky BJ, Guo S, Du L, Leid J, Feng G, Lokshina I, Dmytrenko O, Luehmann H, Bajpai G, Ewald L, Bell L, Patel N, Bredemeyer A, Weinheimer CJ, Nigro JM, Kovacs A, Morimoto S, Bayguinov PO, Fisher MR, Stump WT, Greenberg M, Fitzpatrick JAJ, Epelman S, Kreisel D, Sah R, Liu Y, Hu H, Lavine KJ. Wong NR, et al. Immunity. 2021 Sep 14;54(9):2072-2088.e7. doi: 10.1016/j.immuni.2021.07.003. Epub 2021 Jul 27. Immunity. 2021. PMID: 34320366 Free PMC article.
Selective loss of resident macrophage-derived insulin-like growth factor-1 abolishes adaptive cardiac growth to stress.
Zaman R, Hamidzada H, Kantores C, Wong A, Dick SA, Wang Y, Momen A, Aronoff L, Lin J, Razani B, Mital S, Billia F, Lavine KJ, Nejat S, Epelman S. Zaman R, et al. Immunity. 2021 Sep 14;54(9):2057-2071.e6. doi: 10.1016/j.immuni.2021.07.006. Epub 2021 Aug 6. Immunity. 2021. PMID: 34363749

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In matters of the heart, (cellular) communication is key

Affiliations

In matters of the heart, (cellular) communication is key

Authors

Affiliations

Abstract

Conflict of interest statement

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