SPYing on triplet repeat expansions: Insights into FAN1-MLH1 interaction and regulation
- PMID: 34525375
- DOI: 10.1016/j.celrep.2021.109736
SPYing on triplet repeat expansions: Insights into FAN1-MLH1 interaction and regulation
Abstract
The DNA repair proteins FAN1 and MLH1 have opposing effects on triplet repeat expansions. New studies by Goold et al. (2021) and Porro et al. (2021) pinpoint interactions between FAN1 and MLH1 that cross-regulate each other's activities.
Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.
Comment on
-
FAN1-MLH1 interaction affects repair of DNA interstrand cross-links and slipped-CAG/CTG repeats.Sci Adv. 2021 Jul 30;7(31):eabf7906. doi: 10.1126/sciadv.abf7906. Print 2021 Jul. Sci Adv. 2021. PMID: 34330701 Free PMC article.
-
FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington's disease.Cell Rep. 2021 Aug 31;36(9):109649. doi: 10.1016/j.celrep.2021.109649. Cell Rep. 2021. PMID: 34469738 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
