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Review
. 2021 Aug 30:12:724725.
doi: 10.3389/fphar.2021.724725. eCollection 2021.

Current Molecular Therapeutic Agents and Drug Candidates for Mycobacterium abscessus

Nguyen Thanh Quang  1 , Jichan Jang  1
Affiliations
Review

Current Molecular Therapeutic Agents and Drug Candidates for Mycobacterium abscessus

Nguyen Thanh Quang et al. Front Pharmacol. .

Abstract

Mycobacterium abscessus has been recognised as a dreadful respiratory pathogen among the non-tuberculous mycobacteria (NTM) because of misdiagnosis, prolonged therapy with poor treatment outcomes and a high cost. This pathogen also shows extremely high antimicrobial resistance against current antibiotics, including the anti-tuberculosis agents. Therefore, current chemotherapies require a long curative period and the clinical outcomes are not satisfactory. Thus, there is an urgent need for discovering and developing novel, more effective anti-M. abscessus drugs. In this review, we sum the effectiveness of the current anti-M. abscessus drugs and drug candidates. Furthermore, we describe the shortcomings and difficulties associated with M. abscessus drug discovery and development.

Keywords: Mycobacterium abscessus; anti-M. abscessus; antibiotics; drug discovery; drug resistance.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Mechanisms of action (MOA) of anti-Mab drugs and drug candidates.
See this image and copyright information in PMC

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