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. 2010 Jul;7(1):1-8.

The epigenetics of memory storage in the brain

Affiliations

The epigenetics of memory storage in the brain

R Ryley Parrish et al. Cellscience. 2010 Jul.

Abstract

Epigenetics has been proposed as a molecular mechanism involved in encoding long-term memories. Specifically DNA methylation, an epigenetic mechanism thought to be static following cell differentiation, has been implicated as a dynamic transcription regulatory mechanism underlying the process of longterm memory storage. Now recent findings published in Nature Neuroscience explore the possibility that stable DNA methylation changes within the cortex contributes to memory maintenance.

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References

    1. Alarcon JM, Malleret G, Touzani K, Vronskaya S, Ishii S, Kandel ER, Barco A. Chromatin acetylation, memory, and LTP are impaired in CBP+/− mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration. Neuron. 2004;42:947–959. - PubMed
    1. Bird A. Perceptions of epigenetics. Nature. 2007;447:396–398. - PubMed
    1. Blum S, Hebert AE, Dash PK. A role for the prefrontal cortex in recall of recent and remote memories. Neuroreport. 2006;17:341–344. - PubMed
    1. Bozon B, Davis S, Laroche S. A requirement for the immediate early gene zif268 in reconsolidation of recognition memory after retrieval. Neuron. 2003;40:695–701. - PubMed
    1. Bredy TW, Wu H, Crego C, Zellhoefer J, Sun YE, Barad M. Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear. Learn Mem. 2007;14:268–276. - PMC - PubMed

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