The epigenetics of memory storage in the brain
- PMID: 34527072
- PMCID: PMC8439273
The epigenetics of memory storage in the brain
Abstract
Epigenetics has been proposed as a molecular mechanism involved in encoding long-term memories. Specifically DNA methylation, an epigenetic mechanism thought to be static following cell differentiation, has been implicated as a dynamic transcription regulatory mechanism underlying the process of longterm memory storage. Now recent findings published in Nature Neuroscience explore the possibility that stable DNA methylation changes within the cortex contributes to memory maintenance.
References
-
- Alarcon JM, Malleret G, Touzani K, Vronskaya S, Ishii S, Kandel ER, Barco A. Chromatin acetylation, memory, and LTP are impaired in CBP+/− mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration. Neuron. 2004;42:947–959. - PubMed
-
- Bird A. Perceptions of epigenetics. Nature. 2007;447:396–398. - PubMed
-
- Blum S, Hebert AE, Dash PK. A role for the prefrontal cortex in recall of recent and remote memories. Neuroreport. 2006;17:341–344. - PubMed
-
- Bozon B, Davis S, Laroche S. A requirement for the immediate early gene zif268 in reconsolidation of recognition memory after retrieval. Neuron. 2003;40:695–701. - PubMed
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