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. 2021 Sep 7:8:2333794X211044115.
doi: 10.1177/2333794X211044115. eCollection 2021.

The Effect of Infant Formulas With 4 or 8 g/L GOS/FOS on Growth, Gastrointestinal Symptoms, and Behavioral Patterns: A Prospective Cohort Study

Karina Merini Tonon  1 , Thaís Moreno Tomé  2 , Elaine Martins Bento Mosquera  2 , Natália Pratis Perina  2 , Tamara Lazarini  2
Affiliations

The Effect of Infant Formulas With 4 or 8 g/L GOS/FOS on Growth, Gastrointestinal Symptoms, and Behavioral Patterns: A Prospective Cohort Study

Karina Merini Tonon et al. Glob Pediatr Health. .

Abstract

There is a lack of studies investigating the clinical benefits of prebiotic-supplemented infant formula. In this study, healthy infants that started, on medical recommendation, artificial feeding with one of 2 infant formulas containing 4 g/L of GOS/FOS (9:1) (IF4 group; n = 60) or 8 g/L of GOS/FOS (9:1) (IF8 group; n = 60) were followed for 30 days to the evaluation of growth and gastrointestinal symptoms. Exclusively breastfed infants (EBF; n = 60) were followed up as a reference. Both infant formulas supported adequate weight gain, however, IF4 formula promotes growth more similar to breastfed infants. There was no additional benefit of a dose higher than 4 g/L of GOS/FOS on gastrointestinal symptoms.

Keywords: infant formula; prebiotics; stool consistency; stool frequency; weight gain.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: KMT received fees for scientific consulting from Nestlé Brazil LTDA., TMT, EMBM, NPP, and TL are current employees of Nestlé Brazil LTDA.

Figures

Figure 1.
Figure 1.
BMI-for-age (A), weight-for-length (B), stool frequency (C), and stool consistency (D) in all groups at V2. Stool consistency rating from 1 (liquid) to 5 (hard). Asterisks indicate statistical significance at P < .05. Whiskers indicate the minimum and maximum values, except outliers.
See this image and copyright information in PMC

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