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. 1978 Feb;75(2):928-30.
doi: 10.1073/pnas.75.2.928.

Comutagenic effect of norharman and harman with 2-acetylaminofluorene derivatives

K Umezawa, A Shirai, T Matsushima, T Sugimura

Comutagenic effect of norharman and harman with 2-acetylaminofluorene derivatives

K Umezawa et al. Proc Natl Acad Sci U S A. 1978 Feb.

Abstract

Norharman enhanced the known mutagenicity of 2-acetylaminofluorene derivatives in the Salmonella test system. The mutagenicities of 2-acetylaminofluorene, 2-aminofluorene, and N-hydroxy-2-acetylaminofluorene were enhanced by norharman only when rat liver microsomal enzymes were added, whereas the mutagenicity of N-acetoxy-2-acetylaminofluorene was increased in the absence of microsomal enzymes. Harman also increased mutagenesis, althouth less so than norharman.

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