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. 2021 Sep 16;11(1):91.
doi: 10.1186/s13550-021-00830-6.

CERMEP-IDB-MRXFDG: a database of 37 normal adult human brain [18F]FDG PET, T1 and FLAIR MRI, and CT images available for research

Inés Mérida #  1   2 , Julien Jung #  3   4 , Sandrine Bouvard  5 , Didier Le Bars  6   4 , Sophie Lancelot  6   3   4 , Franck Lavenne  6 , Caroline Bouillot  6 , Jérôme Redouté  6 , Alexander Hammers #  7   8 , Nicolas Costes #  6
Affiliations

CERMEP-IDB-MRXFDG: a database of 37 normal adult human brain [18F]FDG PET, T1 and FLAIR MRI, and CT images available for research

Inés Mérida et al. EJNMMI Res. .

Abstract

We present a database of cerebral PET FDG and anatomical MRI for 37 normal adult human subjects (CERMEP-IDB-MRXFDG). Thirty-nine participants underwent static [18F]FDG PET/CT and MRI, resulting in [18F]FDG PET, T1 MPRAGE MRI, FLAIR MRI, and CT images. Two participants were excluded after visual quality control. We describe the acquisition parameters, the image processing pipeline and provide participants' individual demographics (mean age 38 ± 11.5 years, range 23-65, 20 women). Volumetric analysis of the 37 T1 MRIs showed results in line with the literature. A leave-one-out assessment of the 37 FDG images using Statistical Parametric Mapping (SPM) yielded a low number of false positives after exclusion of artefacts. The database is stored in three different formats, following the BIDS common specification: (1) DICOM (data not processed), (2) NIFTI (multimodal images coregistered to PET subject space), (3) NIFTI normalized (images normalized to MNI space). Bona fide researchers can request access to the database via a short form.

Keywords: CT; Database sharing; Healthy subjects; MRI; Neuroimaging; PET-FDG.

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Conflict of interest statement

The authors have no relevant financial or non-financial interests to disclose.

Figures

Fig. 1
Fig. 1
Example of coregistered T1 MRI, FLAIR MRI, CT and [18F]FDG PET images (sagittal plane) for one subject of the database
Fig. 2
Fig. 2
Example of normalized T1 MRI, FLAIR MRI, CT and [18F]FDG PET images (sagittal plane) in MNI space, for one subject of the database
Fig. 3
Fig. 3
Boxplot of regional SUV for all subjects in the database. Centre lines correspond to medians, boxes to interquartile ranges, and whiskers to robust ranges. Outliers are represented as dots. Each dot represents a participant for unpaired regions and a participant’s right or left SUV value for paired regions
Fig. 4
Fig. 4
Boxplot pf regional activity normalized by mean activity in ICV mask (SPM) for all subjects in the database. Centre lines correspond to medians, boxes to interquartile ranges, and whiskers to robust ranges. Outliers are represented as dots
See this image and copyright information in PMC

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