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Comment
. 2021 Sep 17;373(6561):eabi5459.
doi: 10.1126/science.abi5459. Epub 2021 Sep 16.

Comment on "Aberrant type 1 immunity drives susceptibility to mucosal fungal infections"

Anne Puel  1   2   3   4 , Jean-Laurent Casanova  1   2   3   4
Affiliations
Comment

Comment on "Aberrant type 1 immunity drives susceptibility to mucosal fungal infections"

Anne Puel et al. Science. .

Abstract

Break et al. (Research Articles, 15 January 2021, eaay5731) suggest that chronic mucocutaneous candidiasis in humans with inborn errors of AIRE and autoimmune polyendocrine syndrome type 1 is due to excessive interferon-γ production and not to autoantibodies neutralizing interleukin-17 cytokines. We argue that both claims are not conclusively supported by their data and are at odds with 35 years of study.

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Comment in

  • Response to Comments on "Aberrant type 1 immunity drives susceptibility to mucosal fungal infections".
    Break TJ, Oikonomou V, Dutzan N, Desai JV, Swidergall M, Freiwald T, Chauss D, Harrison OJ, Alejo J, Williams DW, Pittaluga S, Lee CR, Bouladoux N, Swamydas M, Hoffman KW, Greenwell-Wild T, Bruno VM, Rosen LB, Lwin W, Renteria A, Pontejo SM, Shannon JP, Myles IA, Olbrich P, Ferré EMN, Schmitt M, Martin D; Genomics and Computational Biology Core16; Barber DL, Solis NV, Notarangelo LD, Serreze DV, Matsumoto M, Hickman HD, Murphy PM, Anderson MS, Lim JK, Holland SM, Filler SG, Afzali B, Belkaid Y, Moutsopoulos NM, Lionakis MS. Break TJ, et al. Science. 2021 Sep 17;373(6561):eabi8835. doi: 10.1126/science.abi8835. Epub 2021 Sep 16. Science. 2021. PMID: 34529475 Free PMC article.

Comment on

  • Aberrant type 1 immunity drives susceptibility to mucosal fungal infections.
    Break TJ, Oikonomou V, Dutzan N, Desai JV, Swidergall M, Freiwald T, Chauss D, Harrison OJ, Alejo J, Williams DW, Pittaluga S, Lee CR, Bouladoux N, Swamydas M, Hoffman KW, Greenwell-Wild T, Bruno VM, Rosen LB, Lwin W, Renteria A, Pontejo SM, Shannon JP, Myles IA, Olbrich P, Ferré EMN, Schmitt M, Martin D; Genomics and Computational Biology Core; Barber DL, Solis NV, Notarangelo LD, Serreze DV, Matsumoto M, Hickman HD, Murphy PM, Anderson MS, Lim JK, Holland SM, Filler SG, Afzali B, Belkaid Y, Moutsopoulos NM, Lionakis MS. Break TJ, et al. Science. 2021 Jan 15;371(6526):eaay5731. doi: 10.1126/science.aay5731. Science. 2021. PMID: 33446526 Free PMC article.

References

    1. Husebye ES, Anderson MS, Kampe O, Autoimmune polyendocrine syndromes. N Engl J Med 378, 1132–1141 (2018). - PMC - PubMed
    1. Anderson MS et al. , Projection of an immunological self shadow within the thymus by the aire protein. Science 298, 1395–1401 (2002). - PubMed
    1. Break TJ et al. , Aberrant type 1 immunity drives susceptibility to mucosal fungal infections. Science 371, (2021). - PMC - PubMed
    1. Bastard P et al. , Autoantibodies against type I IFNs in patients with life-threatening COVID-19. Science 370, (2020). - PMC - PubMed
    1. Puel A et al. , Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. Science 332, 65–68 (2011). - PMC - PubMed