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Observational Study
. 2021 Sep 16;21(1):956.
doi: 10.1186/s12879-021-06652-0.

Prognostic factors and outcomes of COVID-19 cases in Ethiopia: multi-center cohort study protocol

Saro Abdella  1 , Masresha Tessema  2 , Geremew Tasew  1 , Atkure Defar  1 , Asefa Deressa  1 , Feyisa Regasa  1 , Frehiwot Teka  1 , Eyasu Tigabu  1 , Dereje Nigussie  1 , Tefera Belachew  3 , Million Molla  4 , Amare Deribew  5 , Workeabeba Abebe  6 , Tegbar Yigzaw  7 , Tsinuel Nigatu  8 , Getnet Mitike  9 , Tewodros Haile  6 , Haftom Taame  10 , Muhammed Ahmed  1 , Frehiwot Nigatu  9 , Tola Tolesa  11 , Eskinder Wolka  9 , Wondwossen Amogne  11 , Arnaud Laillou  12 , Misker Amare  1 , Yaregal Fufa  1 , Alemayehu Argaw  3 , Woldesenbet Waganew  13 , Akilili Azazh  13 , Aschalew Worku  13 , Berhane Redae  13 , Menbeu Sultan  13 , Miraf Walelegn  13 , Muluwork Tefera  13 , Sisay Yifru  13 , Rahel Argaw  13 , Natinael Brehau  14 , Sisay Teklu  13 , Getachew Demoz  14 , Yakob Seman  13 , Mihretab Salasibew  15 , Eshetu Ejeta  1 , Susan J Whiting  16 , Dawit Wolday  17 , Getachew Tollera  1 , Ebba Abate  1 , Dereje Duguma  13
Affiliations
Observational Study

Prognostic factors and outcomes of COVID-19 cases in Ethiopia: multi-center cohort study protocol

Saro Abdella et al. BMC Infect Dis. .

Abstract

Background: The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) and became pandemic after emerging in Wuhan, China, in December 2019. Several studies have been conducted to understand the key features of COVID-19 and its public health impact. However, the prognostic factors of COVID-19 are not well studied in the African setting. In this study, we aim to determine the epidemiological and clinical features of COVID-19 cases, immunological and virological courses, interaction with nutritional status, and response to treatment for COVID-19 patients in Ethiopia.

Methods: A multi-center cohort study design will be performed. Patients with confirmed COVID-19 infection admitted to selected treatment centers will be enrolled irrespective of their symptoms and followed-up for 12 months. Baseline epidemiological, clinical, laboratory and imaging data will be collected from treatment records, interviews, physical measurements, and biological samples. Follow-up data collection involves treatment and prognostic outcomes to be measured using different biomarkers and clinical parameters. Data collection will be done electronically using the Open Data Kit (ODK) software package and then exported to STATA/SPSS for analysis. Both descriptive and multivariable analyses will be performed to assess the independent determinants of the treatment outcome and prognosis to generate relevant information for informed prevention and case management. The primary outcomes of this study are death/survival and viral shedding. Secondary outcomes include epidemiological characteristics, clinical features, genetic frequency shifts (genotypic variations), and nutritional status.

Discussion: This is the first large prospective cohort study of patients in hospitals with COVID-19 in Ethiopia. The results will enable us to better understand the epidemiology of SARS-CoV-2 in Africa. This study will also provide useful information for effective public health measures and future pandemic preparedness and in response to outbreaks. It will also support policymakers in managing the epidemic based on scientific evidence.

Trial registration: The Protocol prospectively registered in ClinicalTrials.gov (NCT04584424) on 30 October, 2020.

Keywords: COVID-19; Cohort; Ethiopia; Outcomes of COVID; Prognostic Factors.

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Conflict of interest statement

The authors declare that they have no competing interests.

References

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