Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Sep 16;22(1):311.
doi: 10.1186/s12882-021-02521-9.

Association of uric acid and uric acid to creatinine ratio with chronic kidney disease in hypertensive patients

Nathalia Rabello Silva  1 , Camila Evangelista Torres Gonçalves  1 , Danilo Lemes Naves Gonçalves  1 , Rosângela Minardi Mitre Cotta  2 , Luciana Saraiva da Silva  3
Affiliations

Association of uric acid and uric acid to creatinine ratio with chronic kidney disease in hypertensive patients

Nathalia Rabello Silva et al. BMC Nephrol. .

Abstract

Background: Recent studies have shown that the serum uric acid/creatinine ratio (SUA/SCr) is a better predictor of chronic kidney disease (CKD) than serum uric acid (SUA) isolated. The aim of the present study was to evaluate the association of isolated SUA and the SUA/SCr with CKD in hypertensive patients.

Methods: Cross-sectional study conducted with hypertensive patients followed-up by the Primary Health Care Service (PHC). Sociodemographic, economic, lifestyle, clinical, anthropometric, and biochemical variables were evaluated. The association between SUA parameters (quartiles of SUA and quartiles of SUA/SCr) and CKD was evaluated by bivariate and multivariate logistic regression. The association between SUA parameters (SUA and SUA/SCr) and estimated glomerular filtration rate (eGFR) was evaluated by linear regression. The analyses were performed considering four adjustment models. SUA and SUA/SCr were compared by receiver operating characteristic (ROC) curve.

Results: In the fully adjusted model, SUA was positively associated with the presence of CKD (OR = 6.72 [95 % CI 1.96-22.96]) and inversely associated with eGFR (β Coef. = -2.41 [95 % CI -3.44; -1.39]). SUA/SCr was positively associated with eGFR (β Coef. = 2.39 [1.42; 3.36]). According to the ROC curve, the SUA is a better predictor of CKD than the SUA/SCr.

Conclusions: Elevated levels of isolated SUA were associated with CKD and eGFR. However, the SUA/SCr was not associated with CKD. We do not recommend using the SUA/SCr to predict CKD in hypertensive patients.

Keywords: Chronic kidney disease; Creatinine; Hypertension; Uric acid.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
ROC curve of SUA and SUA/Scr as predictors of CKD
See this image and copyright information in PMC

References

    1. Jager KJ, Kovesdy C, Langham R, Rosenberg M, Jha V, Zoccali C. A single number for advocacy and communication-worldwide more than 850 million individuals have kidney diseases. Nephrology Dialysis Transplantation. 2019;34:1803–5. doi: 10.1093/ndt/gfz174. - DOI - PubMed
    1. Bikbov B, Purcell CA, Levey AS, Smith M, Abdoli A, Abebe M, et al. Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2020;395:709–33. doi: 10.1016/S0140-6736(20)30045-3. - DOI - PMC - PubMed
    1. Kang DH, Ha SK. Uric acid puzzle: Dual role as anti-oxidantand pro-oxidant. Electrolyte and Blood Pressure. 2014;12:1–6. doi: 10.5049/EBP.2014.12.1.1. - DOI - PMC - PubMed
    1. Sautin YY, Johnson RJ. Uric acid: The oxidant-antioxidant paradox. In: Nucleosides, Nucleotides and Nucleic Acids. NIH Public Access; 2008. p. 608–19. doi:10.1080/15257770802138558. - PMC - PubMed
    1. Barata R, Cardoso F, Pereira T. Hyperuricemia in Chronic Kidney Disease: a role yet to be explained. Port J Nephrol Hypertens. 2020;34:30–5. doi: 10.32932/pjnh.2020.04.060. - DOI

Publication types