Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2022 Feb 3;59(2):2102245.
doi: 10.1183/13993003.02245-2021. Print 2022 Feb.

Long COVID: to investigate immunological mechanisms and sex/gender related aspects as fundamental steps for tailored therapy

Affiliations
Editorial

Long COVID: to investigate immunological mechanisms and sex/gender related aspects as fundamental steps for tailored therapy

Elena Ortona et al. Eur Respir J. .

Abstract

Long COVID was detected in both adults and children and is characterised by immunological dysregulation. Autoimmune reactions in adult patients and allergic reactions in children appear to be critical factors. https://bit.ly/38RfSyT

PubMed Disclaimer

Conflict of interest statement

Conflicts of interest: The authors declare no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Possible concurrent mechanisms leading to long COVID.

Comment on

  • Risk factors for post-COVID-19 condition in previously hospitalised children using the ISARIC Global follow-up protocol: a prospective cohort study.
    Osmanov IM, Spiridonova E, Bobkova P, Gamirova A, Shikhaleva A, Andreeva M, Blyuss O, El-Taravi Y, DunnGalvin A, Comberiati P, Peroni DG, Apfelbacher C, Genuneit J, Mazankova L, Miroshina A, Chistyakova E, Samitova E, Borzakova S, Bondarenko E, Korsunskiy AA, Konova I, Hanson SW, Carson G, Sigfrid L, Scott JT, Greenhawt M, Whittaker EA, Garralda E, Swann OV, Buonsenso D, Nicholls DE, Simpson F, Jones C, Semple MG, Warner JO, Vos T, Olliaro P, Munblit D; and the Sechenov StopCOVID Research Team. Osmanov IM, et al. Eur Respir J. 2022 Feb 3;59(2):2101341. doi: 10.1183/13993003.01341-2021. Print 2022 Feb. Eur Respir J. 2022. PMID: 34210789 Free PMC article.

References

    1. Yelin D, Wirtheim E, Vetter P, et al. . Long-term consequences of COVID-19: research needs. Lancet Infect Dis 2020; 20: 1115–1117. doi:10.1016/S1473-3099(20)30701-5 - DOI - PMC - PubMed
    1. Sudre CH, Murray B, Varsavsky T, et al. . Attributes and predictors of long COVID. Nat Med 2021; 27: 626–631. doi:10.1038/s41591-021-01292-y - DOI - PMC - PubMed
    1. Fernández-de-Las-Peñas C, Palacios-Ceña D, Gómez-Mayordomo V, et al. . Defining post-COVID symptoms (post-acute COVID, long COVID, persistent post-COVID): an integrative classification. Int J Environ Res Public Health 2021; 18: 2621. doi:10.3390/ijerph18052621 - DOI - PMC - PubMed
    1. Sivan M, Rayner C, Delaney B. Fresh evidence of the scale and scope of long COVID. BMJ 2021; 373: n853. doi:10.1136/bmj.n853 - DOI - PubMed
    1. Osmanov IM, Spiridonova E, Bobkova P, et al. . Risk factors for post-COVID-19 condition in previously hospitalised children using the ISARIC Global follow-up protocol: a prospective cohort study. Eur Respir J 2022; 59: 2101341. doi:10.1183/13993003.01341-2021 - DOI - PMC - PubMed