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. 2022 Mar 1;2022(3).
doi: 10.1101/pdb.prot106997.

Modeling Human Genetic Disorders with CRISPR Technologies in Xenopus

Helen Rankin Willsey  1 , Matthew Guille  2 , Robert M Grainger  3
Affiliations

Modeling Human Genetic Disorders with CRISPR Technologies in Xenopus

Helen Rankin Willsey et al. Cold Spring Harb Protoc. .

Abstract

Combining the power of Xenopus developmental biology with CRISPR-based technologies promises great discoveries in understanding and treating human genetic disorders. Here we provide a practical pipeline for how to go from known disease gene(s) or risk gene(s) of interest to methods for gaining functional insight into the contribution of these genes to disorder etiology in humans.

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