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. 2021 Nov;18(11):2554-2556.
doi: 10.1038/s41423-021-00767-9. Epub 2021 Sep 16.

T cell immune responses to SARS-CoV-2 and variants of concern (Alpha and Delta) in infected and vaccinated individuals

Stanley C Jordan #  1 , Bong-Ha Shin #  2 , Terry-Ann M Gadsden  2 , Maggie Chu  2 , Anna Petrosyan  2 , Catherine N Le  3 , Rachel Zabner  3 , Jillian Oft  3 , Isabel Pedraza  3 , Susan Cheng  4 , Ashley Vo  2 , Noriko Ammerman  2 , Jasmine Plummer  5 , Shili Ge  2 , Max Froch  2 , Anders Berg  6 , Mieko Toyoda  2 , Ruan Zhang  2
Affiliations

T cell immune responses to SARS-CoV-2 and variants of concern (Alpha and Delta) in infected and vaccinated individuals

Stanley C Jordan et al. Cell Mol Immunol. 2021 Nov.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Immune responses in SARS-CoV-2-infected patients and vaccinated individuals.
A, B SARS-CoV-2 Spike-specific CD4+ and CD8+ T cells in healthy, infected and vaccinated individuals. Whole blood was stimulated with Spike peptides, and T cells with dual-cytokine staining were gated. The blue line shows the 0.05% cutoff. C The correlation of Nucleocapsid-specific IgG titers with CD4+ T cell immune responses to one or more of 5 major SARS-CoV-2 proteins in 25 patients. D The correlation between Spike-specific CD4+ T cell immune responses and Spike-specific IgG levels in 13 patients with elevated CD4+ Spike-specific T cell immune responses (IL-2+/TNF-α+ cell% in CD4+ >0.3%). E, F T cell immune responses to ancestral and variant spike peptides are shown. CD4+/CD8+ Spike-specific T cells from infected and vaccinated healthy individuals were assessed for reactivity to ancestral, Alpha variant and Delta variant Spike peptides. Each dot represents one individual. *P = NS; ***p < 0.001.
See this image and copyright information in PMC

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