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. 2019 Apr;23(10):320-322.
doi: 10.4267/2042/38299.

dic(7;9)(p11-13;p11)

Mary J Underdown  1 , Thomas B Russell  1 , Mark J Pettenati  1 , David E Kram  1
Affiliations

dic(7;9)(p11-13;p11)

Mary J Underdown et al. Atlas Genet Cytogenet Oncol Haematol. 2019 Apr.

Abstract

Dicentric (7;9)(p11-13;p11) is a rare but recurrent abnormality in pediatric and adult precursor B acute lymphoblastic leukemia (B-ALL). The rarity precludes a deep understanding of its biology and associated prognosis. However, recent findings have correlated dic(7;9) and PAX5 mutations, highlighting this cytogenetic event's involvement in leukemogenesis and may also shed light on the overall prognosis of dic(7;9) B-ALL.

Keywords: Acute lymphoblastic leukemia; PAX5; chromosome 7; chromosome 9; dicentric translocation.

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Figures

Figure 1:
Figure 1:
dic(7;9)(p11–13;p11) G-banding - Courtesy Cytogenetics Laboratory of the CCRI, Children’s Cancer Research Institute, Vienna.
Figure 2:
Figure 2:
FISH image depicting 7; dic 7–9; 9 with centromeric probes of 7 and 9 fused - Courtesy Department of Pathology, Wake Forest School of Medicine, Winston Salem, USA.
See this image and copyright information in PMC

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