Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Aug 12;13(8):e17126.
doi: 10.7759/cureus.17126. eCollection 2021 Aug.

Role of Vasodilator Therapy in Acute Heart Failure

Aisha Batool  1 , Negar Salehi  2 , Shahzad Chaudhry  3 , Michael Cross  4 , Abdallah Malkawi  4 , Aisha Siraj  5
Affiliations
Review

Role of Vasodilator Therapy in Acute Heart Failure

Aisha Batool et al. Cureus. .

Abstract

Over the past decade, several trials have questioned the efficacy of vasodilator therapy in acute heart failure (AHF) in the absence of uncontrolled hypertension. In this article, we provide a unique review of the most valuable four trials that present the role of vasodilator therapy in the management of patients with AHF. These four trials have evaluated the efficacy of different types of vasodilators such as nesiritide, ulatritide, and serelaxin in the setting of AHF. Also, we compared comprehensive vasodilator therapy versus standard therapy to see if there is any effect on mortality and re-hospitalization.

Keywords: acute heart failure; heart failure; hfref; management; mortality; vasodilator therapy.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

References

    1. Heart disease and stroke statistics-2019 update: a report from the American Heart Association. Benjamin EJ, Muntner P, Alonso A, et al. Circulation. 2019;139:0. - PubMed
    1. Underlying Cause of Death 1999-2019. [Jan;2019 ];https://wonder.cdc.gov/wonder/help/ucd.html 2019
    1. Clinical epidemiology of heart failure. Mosterd A, Hoes AW. Heart. 2007;93:1137–1146. - PMC - PubMed
    1. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Ponikowski P, Voors AA, Anker SD, et al. Eur Heart J. 2016;37:2129–2200. - PubMed
    1. Clinical presentation, management, and in-hospital outcomes of patients admitted with acute decompensated heart failure with preserved systolic function: a report from the Acute Decompensated Heart Failure National Registry (ADHERE) Database. Yancy CW, Lopatin M, Stevenson LW, De Marco T, Fonarow GC. J Am Coll Cardiol. 2006;47:76–84. - PubMed

LinkOut - more resources