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. 1987 Sep;3(3):211-6.
doi: 10.1093/bioinformatics/3.3.211.

A modified Chou and Fasman protein structure algorithm

W W Ralph  1 , T Webster, T F Smith
Affiliations

A modified Chou and Fasman protein structure algorithm

W W Ralph et al. Comput Appl Biosci. 1987 Sep.

Abstract

A FORTRAN program PRSTRC has been developed for protein secondary structure prediction, which is a modified Chou and Fasman (1978) analysis. This implementation carries out a running average of amino acid structure occurrence frequencies, utilizes a simple set of nucleation conditions, and allows user control over nucleation threshold and cutoff parameters. The algorithm includes prediction of the newly defined secondary structure elements: omega loops (1986). It also generates a charge distribution and hydropathy profile. Output includes a simple graphic display for a printer, or a CRT using color addition. Correct structures are predicted for T. dyscritum hemerythrin and the variable domain of mouse immunoglobin k-chain.

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