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. 2021 Aug;9(15):1235.
doi: 10.21037/atm-21-3037.

Comparison of in vitro maturation and in vitro fertilization for polycystic ovary syndrome patients: a systematic review and meta-analysis

Yalan Xu  1   2   3   4   5 , Jie Qiao  1   2   3   4   5
Affiliations

Comparison of in vitro maturation and in vitro fertilization for polycystic ovary syndrome patients: a systematic review and meta-analysis

Yalan Xu et al. Ann Transl Med. 2021 Aug.

Abstract

Background: There are two common treatments for polycystic ovary syndrome (PCOS): in vitro fertilization (IVF) and in vitro maturation (IVM). Our study aimed to assess the clinical effects and safety of IVM versus IVF for PCOS.

Methods: We searched randomized controlled trials and retrospective cohort studies comparing IVM versus IVF for PCOS. Data were extracted from eligible studies. We sought to evaluate fertilization rate, clinical pregnancy rate, live birth rate, and miscarriage. Results were expressed as risk ratio (RR) with 95% confidence intervals (CIs).

Results: Eight studies with a total of 1,579 patients were included in the present study. According to the heterogeneity analysis, there were no differences between the IVM group and IVF group in terms of fertilization rate, clinical pregnancy rate and miscarriage. Additionally, the IVF group had a higher live birth rate than the IVM group (overall P=0.0007). Sensitivity analysis and funnel plot showed that our study was robust and based on the funnel plot this article had low publication bias.

Discussion: The findings of the present study indicated that IVM had similar clinical effects compared with IVF in patients with PCOS. However, IVM might be a suitable option for PCOS in terms of cost and successful pregnancy rate.

Keywords: In vitro maturation (IVM); in vitro fertilization (IVF); meta-analysis; polycystic ovary syndrome (PCOS).

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Conflict of interest statement

Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at https://dx.doi.org/10.21037/atm-21-3037). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Flowchart of inclusion.
Figure 2
Figure 2
Assessment of the quality of the included studies: low risk of bias (green), unclear risk of bias (yellow), and high risk of bias (red).
Figure 3
Figure 3
Quality assessment of included studies.
Figure 4
Figure 4
Forest plots of fertilization rate between IVM and IVF. IVM, in vitro maturation; IVF, in vitro fertilization; CI, confidence interval.
Figure 5
Figure 5
Forest plots of clinical pregnancy rate between IVM and IVF. IVM, in vitro maturation; IVF, in vitro fertilization; CI, confidence interval.
Figure 6
Figure 6
Forest plots of live birth rate between IVM and IVF. IVM, in vitro maturation; IVF, in vitro fertilization; CI, confidence interval.
Figure 7
Figure 7
Forest plots of miscarriage between IVM and IVF. IVM, in vitro maturation; IVF, in vitro fertilization; CI, confidence interval.
Figure 8
Figure 8
Sensitivity analysis forest plots of fertilization rate between IVM and IVF. IVM, in vitro maturation; IVF, in vitro fertilization; CI, confidence interval.
Figure 9
Figure 9
Funnel plot: Each circle represents one included article. If the figure symmetry is good, the publication bias is small.
See this image and copyright information in PMC

Comment in

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