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. 2022 Apr;35(3):269-279.
doi: 10.1002/ca.23788. Epub 2021 Oct 1.

Tractography of the ansa lenticularis in the human brain

Mengjun Li  1 , Eduardo Carvalhal Ribas  2 , Zhiping Zhang  1 , Xiaolong Wu  1 , Xu Wang  1 , Xiaohai Liu  1 , Jiantao Liang  1 , Ge Chen  1 , Mingchu Li  1
Affiliations

Tractography of the ansa lenticularis in the human brain

Mengjun Li et al. Clin Anat. 2022 Apr.

Abstract

The aim of this study was to make a thorough investigation of the trajectory of the ansa lenticularis (AL) and its subcomponents using high-resolution fiber-tracking tractography. The subcomponents of the AL were reconstructed from one region of interest (ROI) in the area of the globus pallidus combined with another ROI in the red nucleus, substantia nigra, subthalamic nucleus, or thalamus. This fiber-tracking protocol was tested in an HCP-1065 template, 35 healthy subjects from Massachusetts General Hospital (MGH), and 20 healthy subjects from the human connectome project (HCP) using generalized q-sampling imaging (GQI)-based tractography. Quantitative anisotropy and fractional anisotropy were also computed for the AL subcomponents. The subcomponents of the AL could be reconstructed in the HCP-1065 template, 35 MGH healthy subjects, and 20 HCP healthy subjects. The AL descends from the globus pallidus and joins the ansa peduncularis for a short distance, subdividing later into fibers that continue separately to the red nucleus, substantia nigra, subthalamic nucleus, and thalamus. The study demonstrated the trajectory of the ansa lenticularis and its subcomponents using GQI-based tractography, improving our understanding of the anatomical connectivity between the globus pallidus and the thalamo-subthalamic region in the human brain. One Sentence Summary The investigation of the ansa lenticularis and its subcomponents using high-resolution diffusion images based tractography.

Keywords: ansa lenticularis; generalized Q-sampling imaging; globus pallidus; tractography; white matter.

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References

REFERENCES

    1. Adil, S. M., Calabrese, E., Charalambous, L. T., Cook, J. J., Rahimpour, S., Atik, A. F., Cofer, G. P., Parente, B. A., Johnson, G. A., Lad, S. P., & White, L. E. (2021). A high-resolution interactive atlas of the human brainstem using magnetic resonance imaging. NeuroImage, 237, 118135.
    1. Aggarwal, M., Zhang, J., Pletnikova, O., Crain, B., Troncoso, J., & Mori, S. (2013). Feasibility of creating a high-resolution 3D diffusion tensor imaging based atlas of the human brainstem: A case study at 11.7 T. NeuroImage, 74, 117-127. https://doi.org/10.1016/j.neuroimage.2013.01.061
    1. Alarcon, C., De Notaris, M., Palma, K., Soria, G., Weiss, A., Kassam, A., & Prats-Galino, A. (2014). Anatomic study of the central core of the cerebrum correlating 7-T magnetic resonance imaging and fiber dissection with the aid of a neuronavigation system. Neurosurgery, 10(Suppl 2), 294-304.
    1. Calabrese, E., Hickey, P., Hulette, C., Zhang, J., Parente, B., Lad, S. P., & Johnson, G. A. (2015). Postmortem diffusion MRI of the human brainstem and thalamus for deep brain stimulator electrode localization. Human Brain Mapping, 36(8), 3167-3178. https://doi.org/10.1002/hbm.22836
    1. Celtikci, P., Fernandes-Cabral, D. T., Yeh, F. C., Panesar, S. S., & Fernandez-Miranda, J. C. (2018). Generalized q-sampling imaging fiber tractography reveals displacement and infiltration of fiber tracts in low-grade gliomas. Neuroradiology, 60(3), 267-280. https://doi.org/10.1007/s00234-018-1985-5

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