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Randomized Controlled Trial
. 2022 Mar;35(2):181-189.
doi: 10.1111/sdi.13020. Epub 2021 Sep 18.

Intradialytic periodized exercise improves cardiopulmonary fitness and respiratory function: A randomized controlled trial

Francini Porcher Andrade  1 , Gabrielle Costa Borba  1 , Kacylen Costa da Silva  1 , Tatiane de Souza Ferreira  1 , Samantha Gonçalves de Oliveira  2 , Verônica Verleine Hörbe Antunes  2 , Francisco Veríssimo Veronese  2 , Paula Maria Eidt Rovedder  1   3
Affiliations
Randomized Controlled Trial

Intradialytic periodized exercise improves cardiopulmonary fitness and respiratory function: A randomized controlled trial

Francini Porcher Andrade et al. Semin Dial. 2022 Mar.

Abstract

Background: Chronic kidney disease (CKD) is a factor that predisposes to gradual physical deconditioning from its early stages leading to cardiorespiratory fitness and musculoskeletal system impairment. We evaluated the effects of combined and periodized intradialytic exercise training on cardiopulmonary fitness and respiratory function in HD subjects.

Methods: A randomized controlled trial with HD subjects was allocated into two groups: exercise group (EXG) and usual care group (UCG). EXG performed a 12-week combined and periodized intradialytic training. UCG maintained the HD routine.

Results: Thirty-nine HD subjects were analyzed (EXG = 20; UCG = 19). The EXG in comparison with the UCG showed improvements in peak oxygen consumption (Δ3.1[0.4-5.5] vs. -0.2[-2.0-1.5] ml/kg/min; p = 0.003), forced expiratory volume in the first second (Δ0.1[-0.0-0.1] vs. -0.0[-0.1-0.0] L; p = 0.022), forced vital capacity (Δ0.1[0.0-0.2] vs. -0.1[-0.2-0.0] L; p = 0.005), peak expiratory flow (Δ0.4[-0.7-1.2] vs. -0.1[-0.5-0.2] L; p = 0.046), and maximal inspiratory pressure (Δ7.35[-8.5-17.5] vs. -4.0[-18.0-12.0] cmH2 O; p = 0.028). The EXG, different from the UCG, did not worsen the maximal expiratory pressure (Δ0.1[-8.8-7.5] vs. -2.5[-15.0-9.0] cmH2 O; p = 0.036). Besides, EXG showed a significant improvement in quadriceps strength (32.05 ± 10.61 vs. 33.35 ± 11.62 kg; p = 0.042).

Conclusions: The combined and periodized intradialytic exercise training improved cardiopulmonary fitness, respiratory function, inspiratory muscle strength, and quadriceps strength, beyond maintaining the expiratory muscle strength in HD subjects.

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References

REFERENCES

    1. KDIGO. Chapter 1: Definition and classification of CKD. Kidney Int Suppl. 2013 Jan;3(1):19-62. Available from: https://linkinghub.elsevier.com/retrieve/pii/S2157171615311011
    1. Kirkman DL, Muth BJ, Stock JM, Townsend RR, Edwards DG. Cardiopulmonary exercise testing reveals subclinical abnormalities in chronic kidney disease. Eur J Prev Cardiol. 2018;25(16):1717-1724.
    1. de Boer IH, Caramori ML, Chan JCN, et al. KDIGO 2020 clinical practice guideline for diabetes management in chronic kidney disease. Kidney Int. 2020 Oct;98(4):S1-S115.
    1. Yamagata K, Hoshino J, Sugiyama H, et al. Clinical practice guideline for renal rehabilitation: Systematic reviews and recommendations of exercise therapies in patients with kidney diseases. Ren Replace Ther. 2019;5(1):1-19.
    1. Howden EJ, Coombes JS, Strand H, Douglas B, Campbell KL, Isbel NM. Exercise training in CKD: efficacy, adherence, and safety. Am J Kidney Dis. 2015;65(4):583-591.

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