Regression of corpus luteum in cetaceans: A systematic review

Abstract

Functional and structural change of corpus luteum through the cascade of several genes in the ovary leads to ovulation and pregnancy. In most mammals, the absence of pregnancy leads to the disintegration of the corpus luteum. In the ovary of cetaceans, the regression of the corpus luteum gets delayed and persists on the surface as scars (corpus albicans). The database on luteolysis of mammals was collected and examined to know the mechanisms involved in the corpus luteum regression of cetaceans. Surprisingly, there existed no data on the concerned topic. Some past findings reported the persistence of ovarian scars through the entire life span, while few reported the regression. Also, those investigations were about the physiology and histology of corpus luteum regression. The pathways and the genes involved in the regression of the cetacean corpus luteum remain unexplored. This review is all about the regression of corpus luteum and recommends gene-based evolutionary studies in the future to resolve the existing theories on ovarian scar persistence in cetaceans.

Keywords: Cetaceans; Corpus albicans; Corpus luteum; Evolution; Persistence of ovarian scars; Regression.