Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 Oct;42(10):846-848.
doi: 10.1016/j.it.2021.08.011. Epub 2021 Sep 15.

Phagocyte metabolism: neutrophils have their cake but don't eat it

James J Phelan  1 , Frederick J Sheedy  2
Affiliations
Comment

Phagocyte metabolism: neutrophils have their cake but don't eat it

James J Phelan et al. Trends Immunol. 2021 Oct.

Abstract

Selectively targeting facets of neutrophil function could benefit infectious and inflammatory diseases. Amara et al. report on a compound which blocks human neutrophil activation by activating the glycolytic enzyme phosphofructokinase, liver-type (PFKL). Altering glucose fate by modulating this key enzymatic step could dramatically alter the function and fate of phagocytes.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests The authors declare no conflicts of interest.

Comment on

  • Selective activation of PFKL suppresses the phagocytic oxidative burst.
    Amara N, Cooper MP, Voronkova MA, Webb BA, Lynch EM, Kollman JM, Ma T, Yu K, Lai Z, Sangaraju D, Kayagaki N, Newton K, Bogyo M, Staben ST, Dixit VM. Amara N, et al. Cell. 2021 Aug 19;184(17):4480-4494.e15. doi: 10.1016/j.cell.2021.07.004. Epub 2021 Jul 27. Cell. 2021. PMID: 34320407 Free PMC article.

Publication types

LinkOut - more resources