The Impact of Bone Mineral Biomarkers on Cardiac Dysfunction in Predialysis Chronic Kidney Disease Children

Abstract

Objective: To evaluate the association of bone mineral biomarkers of calcium, phosphorus metabolism, and 25-hydroxy vitamin D with diastolic dysfunction of the left ventricle and left ventricle mass in predialysis chronic kidney children. Patients and Methods. A cross-sectional observational study was conducted on 60 children with chronic kidney disease and treated by conservative treatment from October 2018 to September 2019 in the Pediatric Nephrology and Cardiology Department at our University Hospital.

Results: The most common causes of CKD were congenital renal anomalies accounted for 22 (36.67%) of the studied cases. The mean age of children was 7.05 ± 2.74 years, and 32 (53.33%) were males. The children who had a normal diastolic function were 32 (53.33%), while those who had diastolic dysfunction were 28 (46.67%). There was a statistically significant in serum phosphorus (p value = 0.03), serum PTH (p value = 0.002), and hypertension (p value = 0.03). There was a statistically significant positive correlation between LVMI and iPTH level (r = 0.89, p ≤ 0.0001), 25(OH) cholecalciferol (r = -0.27, p = 0.04), serum Ca (r = -0.37, p = 0.004), and serum phosphorus (r = -0.45, p = 0.0003).

Conclusion: Our results revealed that hyperparathyroidism, hyperphosphatemia, and hypertension were significantly associated with diastolic dysfunction while hypovitaminosis D was not significantly associated. Vitamin D deficiency was prevalent in all children with CKD. Biomarkers of mineral bone density were significantly associated with left ventricular hypertrophy and increased left ventricular mass index.

Figure 1

The relation between diastolic dysfunction and 25(OH) cholecalciferol.

Figure 2

The relation between diastolic dysfunction and phosphorus.

Figure 3

Relation between diastolic dysfunction and parathyroid hormone.