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. 2021 Apr-Jun;17(1):42-50.
doi: 10.4183/aeb.2021.42.

Quality of Life in Patients with Acromegaly - A Romanian Single Center Cross-Sectional Study

C L Scânteie  1   2 , D C Leucuţa  3 , C M V Ghervan  1   4
Affiliations

Quality of Life in Patients with Acromegaly - A Romanian Single Center Cross-Sectional Study

C L Scânteie et al. Acta Endocrinol (Buchar). 2021 Apr-Jun.

Abstract

Context: Acromegaly, a severe condition characterized by excessive and unmodulated secretion of growth hormone, leads to morphologic disturbances and multisystem complications.

Objective: The purpose of this study was to evaluate the quality of life (QOL) in patients with acromegaly compared to matched obese patients.

Design: This was an observational cross-sectional study.

Subjects and methods: We enrolled 49 patients with acromegaly and 49 obese patients. AcroQoL (acromegaly QoL questionnaire) was applied to all patients and IGF-1 (type 1 insulin-like growth factor 1) was measured.

Results: Patients with acromegaly had a worse QoL compared to patients with obesity (score= 77(53-86) vs. 96(90-102), p<0.001). In the group of patients with acromegaly, there was no difference in the QoL regarding the activity of the disease (active, controlled, or cured). Men had a higher AcroQoL score than women (score= 88(55-95) vs. 74(52.75-82), p=0.02), but there was no difference between patients with microadenomas and the ones with macroadenomas (score= 82(66-88.5) vs. 73(55-83), p=0.136). The most frequent complications were cardiovascular complications (81.63%), articular complications (73.46%), dyslipidemia (65.30%) and digestive complications (63.26%).

Conclusions: Despite complex treatment and hormonal control, the presence of complications reduces the quality of life in patients with acromegaly, even when compared with obese patients.

Keywords: AcroQoL score; acromegaly; quality of life.

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Figures

Figure 1.
Figure 1.
Percentage of patients with acromegaly suffering from complications.
See this image and copyright information in PMC

References

    1. T’Sjoen G, Bex M, Maiter D, Velkeniers B, Abs R. Health-related quality of life in acromegalic subjects: data from AcroBel, the Belgian Registry on acromegaly. EJE. 2007;57:411–417. - PubMed
    1. Trepp R, Evertst R, Stettler C, Fischli S, Allemann S, Webb SM, Christ ER. Assessment of quality of life in patients with uncontrolled vs. controlled acromegaly using the acromegaly Quality of Life Questionnaire (AcroQoL) Clin Endocrinol (Oxf) 2005;63:103–110. - PubMed
    1. Anagnostis P, Efstathiadou ZA, Charizopoulou M, Selalmatzidou D, Karathanasi E, Poulasouchidou M, Kita M. Psychological profile and quality of life in patients with acromegaly in Greece. Is there any difference with other chronic diseases? Endocrine. 2014 doi: 10.1007/s12020-014-0166-5. - DOI - PubMed
    1. Vandeva S, Yaneva M, Natchev E, Elenkova A, Kalinov K, Zacharieva S. Disease control and treatment modalities have impact on quality of life in acromegaly evaluated by Acromegaly Quality of Life (AcroQoL) Questionnaire. Endocrine. 2015 doi: 10.1007/212020-014-0521-6. - DOI - PubMed
    1. Kauppinen-Makelin R, Sane T, Sintonen H, Markkanen H, Valimaki MJ, Loyttyniemi E, Niskanen L, Reunanen A, Stenman UH, the Finnish Acromegaly Study Group Quality of life in treated patients with acromegaly. J Clin Endocrinol Metab. 2006;91(10):3891–3896. - PubMed

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