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. 2022 Apr 20;32(9):1993-2012.
doi: 10.1093/cercor/bhab332.

Functional Neural Correlates of a Useful Field of View (UFOV)-Based fMRI Task in Older Adults

Jessica N Kraft  1   2 , Alejandro Albizu  1   2 , Andrew O'Shea  1   3 , Hanna K Hausman  1   3 , Nicole D Evangelista  1   3 , Emanuel Boutzoukas  1   3 , Cheshire Hardcastle  1   3 , Emily J Van Etten  4 , Pradyumna K Bharadwaj  4 , Hyun Song  4 , Samantha G Smith  4 , Steven DeKosky  1   5 , Georg A Hishaw  6 , Samuel Wu  7 , Michael Marsiske  1   3 , Ronald Cohen  1   3 , Gene E Alexander  5   6 , Eric Porges  1   3 , Adam J Woods  1   2   3
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Functional Neural Correlates of a Useful Field of View (UFOV)-Based fMRI Task in Older Adults

Jessica N Kraft et al. Cereb Cortex. .

Abstract

Declines in processing speed performance occur in aging and are a critical marker of functional independence in older adults. Studies suggest that Useful Field of View (UFOV) training may ameliorate cognitive decline. Despite its efficacy, little is known about the neural correlates of this task. Within the current study, 233 healthy older adults completed a UFOV-based task while undergoing functional magnetic resonance imaging (fMRI). During the "stimulus" portion of this task, participants must identify a target in the center of the screen and the location of a target in the periphery, among distractors. During the "probe" portion, participants must decide if the object in the center and the location of the target in the periphery were identical to the "stimulus" screen. Widespread bilateral whole-brain activation was observed when activation patterns of the "probe" contrast were subtracted from the "stimulus" contrast. Conversely, the subtraction of "stimulus" from "probe" was associated with discrete activation patterns consisting of 13 clusters. Additionally, when evaluating the variance associated with task accuracy, specific subregions were identified that may be critical for task performance. Our data elucidate the functional neural correlates of a UFOV-based task, a task used in both cognitive training paradigms and assessment of function.

Keywords: BOLD; UFOV; cognitive aging; fMRI; processing speed.

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Figures

Figure 1
Figure 1
Useful Field of View task.
Figure 2
Figure 2
Activation locations in the “stimulus” > “probe” contrast.
Figure 3
Figure 3
Activation locations in the “probe” > “stimulus” contrast.
Figure 4
Figure 4
Activation locations in the “stimulus” > “rest and probe” > “rest” conjunction analysis.
Figure 5
Figure 5
Activation locations in the “stimulus” > “probe with accuracy” contrast.
Figure 6
Figure 6
Activation locations in the “stimulus” > “rest and probe” > “rest with accuracy” conjunction analysis.
See this image and copyright information in PMC

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