Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Dec;83(12):e23331.
doi: 10.1002/ajp.23331. Epub 2021 Sep 20.

Improving rigor and reproducibility in nonhuman primate research

Eliza Bliss-Moreau  1   2 , Rama R Amara  3 , Elizabeth A Buffalo  4   5 , Ricki J Colman  6   7 , Monica E Embers  8 , John H Morrison  1   9 , Ellen E Quillen  10 , Jonah B Sacha  11   12 , Charles T Roberts  11 ; National Primate Research Center Consortium Rigor and Reproducibility Working Group
Affiliations
Review

Improving rigor and reproducibility in nonhuman primate research

Eliza Bliss-Moreau et al. Am J Primatol. 2021 Dec.

Abstract

Nonhuman primates (NHPs) are a critical component of translational/preclinical biomedical research due to the strong similarities between NHP and human physiology and disease pathology. In some cases, NHPs represent the most appropriate, or even the only, animal model for complex metabolic, neurological, and infectious diseases. The increased demand for and limited availability of these valuable research subjects requires that rigor and reproducibility be a prime consideration to ensure the maximal utility of this scarce resource. Here, we discuss a number of approaches that collectively can contribute to enhanced rigor and reproducibility in NHP research.

Keywords: biomedical research; data sharing; nonhuman primates; preregistration; quality assurance.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there are no conflicts of interest.

Figures

Figure 1
Figure 1
Stakeholders and their roles in supporting rigor and reproducibility in nonhuman primate research
See this image and copyright information in PMC

References

    1. Auton, A. , Abecasis, G. R. , Altshuler, D. M. , Durbin, R. M. , Abecasis, G. R. , Bentley, D. R. , National Eye Institute , & N. I. H. (2015). A global reference for human genetic variation. Nature, 526(7571), 68–74. 10.1038/nature15393 - DOI - PMC - PubMed
    1. Bacchetti, P. , Deeks, S. G. , & McCune, J. M. (2011). Breaking free of sample size dogma to perform innovative translational research. Science Translational Medicine, 3(87), 87ps24. 10.1126/scitranslmed.3001628 - DOI - PMC - PubMed
    1. Bauer, P. , Bretz, F. , Dragalin, V. , Konig, F. , & Wassmer, G. (2016). Twenty‐five years of confirmatory adaptive designs: Opportunities and pitfalls. Statistics in Medicine, 35(3), 325–347. 10.1002/sim.6472 - DOI - PMC - PubMed
    1. Bimber, B. N. , Yan, M. Y. , Peterson, S. M. , & Ferguson, B. (2019). mGAP: The macaque genotype and phenotype resource, a framework for accessing and interpreting macaque variant data, and identifying new models of human disease. BMC Genomics, 20(1), 176. 10.1186/s12864-019-5559-7 - DOI - PMC - PubMed
    1. Bolli, R. (2017). New initiatives to improve the rigor and reproducibility of articles published in. Circulation Research, 121(5), 472–479. 10.1161/CIRCRESAHA.117.311678 - DOI - PubMed

Publication types