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Review
. 2021 Jan-Dec:27:10760296211040110.
doi: 10.1177/10760296211040110.

Concern About the Adverse Effects of Thrombocytopenia and Thrombosis After Adenovirus-Vectored COVID-19 Vaccination

M A Haimei  1
Affiliations
Review

Concern About the Adverse Effects of Thrombocytopenia and Thrombosis After Adenovirus-Vectored COVID-19 Vaccination

M A Haimei. Clin Appl Thromb Hemost. 2021 Jan-Dec.

Abstract

Since the outbreak of Covid-19 in December, 2019, scientists worldwide have been committed to developing COVID-19 vaccines. Only when most people have immunity to SARS-CoV-2, COVID-19 can reduce even wholly overcome. So far, nine kinds of COVID-19 vaccines have passed the phase III clinical trials and have approved for use. At the same time, adverse reactions after COVID-19 vaccination have also reported. This paper focuses on the adverse effects of thrombosis and thrombocytopenia caused by the COVID-19 vaccine, especially the adenovirus-vector vaccine from AstraZeneca and Pfizer, and discusses its mechanism and possible countermeasures.

Keywords: COVID-19; SARS-CoV-2; adenovirus-vectored vaccine; adverse effect; thrombocytopenia; thrombosis.

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Conflict of interest statement

Compliance with ethics guidelines: This article does not contain any studies with human or animal subjects performed.

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
HIT and VITT mechanism schematic. Abbreviations: HIT, heparin-induced thrombocytopenia; VITT, vaccine-induced immune thrombotic thrombocytopenia.
See this image and copyright information in PMC

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