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. 2021 Nov 1;78(11):1407-1409.
doi: 10.1001/jamaneurol.2021.2823.

Plasma Biomarkers of Tau and Neurodegeneration During Major Cardiac and Noncardiac Surgery

Igor Feinstein  1 , Edward N Wilson  2 , Michelle S Swarovski  2 , Katrin I Andreasson  2 , Martin S Angst  1 , Michael D Greicius  2
Affiliations

Plasma Biomarkers of Tau and Neurodegeneration During Major Cardiac and Noncardiac Surgery

Igor Feinstein et al. JAMA Neurol. .

Abstract

This analysis compares plasma biomarkers of tau and neurodegeneration during major cardiac and noncardiac surgeries.

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Conflict of interest statement

Conflict of Interest Disclosures: None were reported.

Figures

Figure.
Figure.. pTau181 and Neurofilament Light Chain (NfL) Plasma Concentrations Increase Significantly During the Perioperative Period
A, In patients undergoing cardiac surgery, pTau181 concentrations peak during surgery and remain elevated on postoperative days 1 (POD1) and 2 (POD2). Lines are color coded to distinguish individual patients. B, A similar but less pronounced temporal pattern was observed in patients undergoing hip replacement surgery. C, In patients undergoing cardiac surgery, NfL levels remain flat on the day of surgery, but peak on POD1 and POD2. D, In contrast, no significant elevation of NfL was detected in patients undergoing hip replacement surgery. Data are analyzed by repeated-measures analysis of variance with Tukey post hoc multiple comparisons test. CPB indicates cardiopulmonary bypass. aP < .05. bP < .01. cP < .001.
See this image and copyright information in PMC

References

    1. Newman MF, Kirchner JL, Phillips-Bute B, et al. ; Neurological Outcome Research Group and the Cardiothoracic Anesthesiology Research Endeavors Investigators . Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery. N Engl J Med. 2001;344(6):395-402. doi:10.1056/NEJM200102083440601 - DOI - PubMed
    1. Kapila AK, Watts HR, Wang T, Ma D. The impact of surgery and anesthesia on post-operative cognitive decline and Alzheimer’s disease development: biomarkers and preventive strategies. J Alzheimers Dis. 2014;41(1):1-13. doi:10.3233/JAD-132258 - DOI - PubMed
    1. Evered L, Silbert B, Scott DA, Zetterberg H, Blennow K. Association of changes in plasma neurofilament light and tau levels with anesthesia and surgery: results from the CAPACITY and ARCADIAN studies. JAMA Neurol. 2018;75(5):542-547. doi:10.1001/jamaneurol.2017.4913 - DOI - PMC - PubMed
    1. Janelidze S, Mattsson N, Palmqvist S, et al. . Plasma P-tau181 in Alzheimer’s disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer’s dementia. Nat Med. 2020;26(3):379-386. doi:10.1038/s41591-020-0755-1 - DOI - PubMed
    1. Hesse C, Rosengren L, Andreasen N, et al. . Transient increase in total tau but not phospho-tau in human cerebrospinal fluid after acute stroke. Neurosci Lett. 2001;297(3):187-190. doi:10.1016/S0304-3940(00)01697-9 - DOI - PubMed

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