Unusual presentation of granular cell tumour of buccal mucosa

Abstract

Granular cell tumour (GCT) is a rare soft tissue lesion which many consider to have malignant potential of yet unknown aetiopathogenesis. Oral GCT lesions may occur in an area of leucoplakia and are predominantly present on the tongue. This case study highlights an uncommon presentation of this condition located on the buccal mucosa and illustrates the need for meticulous evaluation of suspicious lesions. Due to the malignant risk associated with GCT lesions, it is important to make the correct diagnosis and ensure complete surgical excision for these cases. Ongoing long-term follow-up is also indicated to monitor for recurrence or malignancy.

Keywords: dentistry and oral medicine; pathology.

Figure 1

Right buccal mucosal clinical view.

Figure 2

H&E stained sections revealing tumour occupying the stroma, composed of polygonal cells with abundant eosinophilic cytoplasm and rounded, cytological bland nuclei. No mitotic figures seen. The cells are positive for S100 and SOX10. The overlying epithelium shows mild thickening with orthokeratosis and parakeratosis.