Cardiac mortality, adequate power, and objective inclusion of the entire evidence are key to accurately define the long-term effect of revascularisation vs. medical therapy alone in stable coronary syndromes

Eliano P Navarese^{1

2

3}, Felicita Andreotti^{4

5}

Affiliations

¹ Interventional Cardiology and Cardiovascular Medicine Research, Department of Cardiology and Internal Medicine, Nicolaus Copernicus University, M. Skłodowskiej-Curie Street No 9, Bydgoszcz 85-094, Poland.
² Faculty of Medicine, Department of Cardiology, 11220 83rd Avenue NW, Edmonton, AB T6G 2B7, Canada.
³ SIRIO MEDICINE Research Network, M. Skłodowskiej-Curie Street No 9, Bydgoszcz 85-094, Poland.
⁴ Dept of Cardiovascular Science, Fondazione Policlinico Universitario Gemelli IRCCS, Largo F. Vito 1, Rome 00168, Italy.
⁵ Catholic University Medical School, Largo F Vito 1, Rome 00168, Italy.

Comment

Eliano P Navarese et al. Eur Heart J. 2021.

. 2021 Dec 1;42(45):4699-4700.

doi: 10.1093/eurheartj/ehab677.

Eliano P Navarese^{1

2

3}, Felicita Andreotti^{4

5}

¹ Interventional Cardiology and Cardiovascular Medicine Research, Department of Cardiology and Internal Medicine, Nicolaus Copernicus University, M. Skłodowskiej-Curie Street No 9, Bydgoszcz 85-094, Poland.
² Faculty of Medicine, Department of Cardiology, 11220 83rd Avenue NW, Edmonton, AB T6G 2B7, Canada.
³ SIRIO MEDICINE Research Network, M. Skłodowskiej-Curie Street No 9, Bydgoszcz 85-094, Poland.
⁴ Dept of Cardiovascular Science, Fondazione Policlinico Universitario Gemelli IRCCS, Largo F. Vito 1, Rome 00168, Italy.
⁵ Catholic University Medical School, Largo F Vito 1, Rome 00168, Italy.

No abstract available

Comment on

Cardiac mortality in patients randomised to elective coronary revascularisation plus medical therapy or medical therapy alone: a systematic review and meta-analysis.
Navarese EP, Lansky AJ, Kereiakes DJ, Kubica J, Gurbel PA, Gorog DA, Valgimigli M, Curzen N, Kandzari DE, Bonaca MP, Brouwer M, Umińska J, Jaguszewski MJ, Raggi P, Waksman R, Leon MB, Wijns W, Andreotti F. Navarese EP, et al. Eur Heart J. 2021 Dec 1;42(45):4638-4651. doi: 10.1093/eurheartj/ehab246. Eur Heart J. 2021. PMID: 34002203 Free PMC article.
Cardiac death should be the primary endpoint for revascularization trials and meta-analyses.
White HD. White HD. Eur Heart J. 2021 Dec 1;42(45):4697-4698. doi: 10.1093/eurheartj/ehab676. Eur Heart J. 2021. PMID: 34545390 No abstract available.