Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987;28(3-4):343-8.
doi: 10.1186/BF03548602.

The influence of feeding and oral rehydration on the bioavailability of oxytetracycline in calves

J Luthman, S O Jacobsson

The influence of feeding and oral rehydration on the bioavailability of oxytetracycline in calves

J Luthman et al. Acta Vet Scand. 1987.

Abstract
in English, German

The influence of feeding on the bioavailability of oxytetracycline was studied in preruminant calves. Oxytetracycline was given in water as a drench to fasting calves or was mixed in the milk replacer. Compared to water the bioavailability was significantly reduced (53.5%) when oxytetracycline was mixed in the milk re-placer. A further reduction, 83.3 %, occurred when the calves were treated one hour post milk feeding. Also concentrate was found to reduce the bioavailability. Very high serum levels were recorded when the drug was given in an oral rehydration solution, pH 4.9, containing glycine. The values obtained when an alkaline (pH 8.3) solution without glycine was used did not differ from the levels recorded when oxytetracycline was given in water. It was suggested that the use of oxytetra-cyclines in feeds may be questioned because of their well-known complex forming ability.

Effekten av utfodring på tillgängligheten av oxitetracyklin studerades hos kalv. Oxitetracyklin gavs i vatten eller blandades i mjölknäringen till fastade kalvar. Jämfört med vatten reducerades tillgängligheten signifikant (53,5 %) när oxitetracyklin blandades i mjölknäringen. Tillgängligheten reducerades ytterligare, 83,3 %, när kalvarna behandlades en timme efter utfodring. Kraftfoder visades också reducera tillgängligheten påtagligt. Mycket höga serumkoncentrationer uppnåddes när oxitetracyklin gavs i en oral rehydreringslösning, pH 4,9, innehållande glycin. De värden som uppnåddes med en alkalisk rehydreringslösning utan glycin, pH 8,3, var inte signifikant skilda från de värden som erhölls med oxitetracyklin i vatten. På grund av tetracyklinernas komplexbildande förmåga kan inblandning i foder under vissa förhållanden ifrågasättas.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Baggot JD: Principles of drug disposition in domestic animals. W. B. Saunders Co. Philadelphia/London/Toronto 1977.
    1. Bengtsson B, Luthman J, Jacobsson SO. Penetration of oxytetracycline into tissue-cages in calves. J. vet. Pharmacol. Therap. 1986;9:71–80. doi: 10.1111/j.1365-2885.1986.tb00014.x. - DOI - PubMed
    1. Bywater RJ. Evaluation of an oral glucose-gly-cine-electrolyte formulation for the treatment of diarrhea in calves. Amer. J. vet. Res. 1977;38:1983–1985. - PubMed
    1. Clary BD, Terry RJ, Creyer CB. The potentiation effects of citric acid on Aureomycin in turkeys. Poultry Sci. 1980;60:1209–1212. doi: 10.3382/ps.0601209. - DOI - PubMed
    1. Coustain RA, Lloyd LE. Effect of ration calcium level, oxytetracycline and terephtalic acid upon the performance of growing pigs. J. Anim.Sci. 1962;27:751–753. doi: 10.2527/jas1962.214751x. - DOI

Substances

LinkOut - more resources