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. 2022 Nov;20(11):2650-2652.e1.
doi: 10.1016/j.cgh.2021.09.013. Epub 2021 Sep 20.

Low Prevalence of Screen-Detected Colorectal Cancer in an Average-Risk Population: The New Normal

A Shaukat  1 , T L Marsh  2 , S D Crockett  3 , S Syngal  4 , R S Bresalier  5 , D E Brenner  6
Affiliations

Low Prevalence of Screen-Detected Colorectal Cancer in an Average-Risk Population: The New Normal

A Shaukat et al. Clin Gastroenterol Hepatol. 2022 Nov.

Abstract

Prior studies have reported the prevalence of colorectal cancer (CRC) in average-risk screening population ages 50-75 to be 0.7%-1.0%.1,2 However, no estimates from studies enrolling individuals undergoing screening colonoscopy have been reported. The experience of ongoing studies enrolling average-risk individuals is that the prevalence rates are substantially lower. A 2020 study from a community-based cohort undergoing CRC screening with fecal immunochemical testing followed by diagnostic colonoscopy reported a CRC prevalence rate of 1.46 per 1000, or 0.15%.3 The aim of our study is to report the screen-detected prevalence of CRC and advanced neoplasia in average-risk asymptomatic individuals from selected academic and community medical centers in the United States, Canada, and Germany and describe associated risk factors.

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Conflict of interest statement

Disclosures:

Shaukat A: Research funding from Freenome Inc.

Crockett SD: Research funding from Exact Sciences, Freenome Inc and Guardant Inc.

No relevant conflicts of interest for any of the other authors

References

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