The tension between clinical and microbiological relevance in applying clinical trial results for Gram negative bacterial infections

Affiliations

¹ Victorian Infectious Diseases Service, The Royal Melbourne Hospital, At the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia; Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia. Electronic address: steven.tong@mh.org.au.
² Department of Emergency Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Berry Consultants, LLC, Austin, TX, USA.
³ Department of Infectious Diseases, Middlemore Hospital, Counties Manukau Health, Auckland, New Zealand.

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Steven Y C Tong et al. Clin Microbiol Infect. 2021 Dec.

Free article

. 2021 Dec;27(12):1733-1735.

doi: 10.1016/j.cmi.2021.09.011. Epub 2021 Sep 20.

¹ Victorian Infectious Diseases Service, The Royal Melbourne Hospital, At the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia; Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia. Electronic address: steven.tong@mh.org.au.
² Department of Emergency Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Berry Consultants, LLC, Austin, TX, USA.
³ Department of Infectious Diseases, Middlemore Hospital, Counties Manukau Health, Auckland, New Zealand.

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A systematic review of antimicrobial susceptibility testing as a tool in clinical trials assessing antimicrobials against infections due to gram-negative pathogens.
Henderson A, Bursle E, Stewart A, Harris PNA, Paterson D, Chatfield MD, Paul M, Dickstein Y, Rodriguez-Baño J, Turnidge JD, Kahlmeter G. Henderson A, et al. Clin Microbiol Infect. 2021 Dec;27(12):1746-1753. doi: 10.1016/j.cmi.2021.03.019. Epub 2021 Apr 1. Clin Microbiol Infect. 2021. PMID: 33813125