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. 2021 Aug;43(8):595-599.
doi: 10.1055/s-0041-1733912. Epub 2021 Sep 21.

COVID-19 in Pregnancy: Implication on Platelets and Blood Indices

Wassan Nori  1 , Ban Hadi Hameed  1 , Asmaa Rajih Thamir  2 , Amenah Fadhil  1
Affiliations

COVID-19 in Pregnancy: Implication on Platelets and Blood Indices

Wassan Nori et al. Rev Bras Ginecol Obstet. 2021 Aug.

Abstract
in English, Portuguese

Objective: To describe the hematological changes, the platelet indices in particular, in pregnant women with coronavirus disease 2019 (COVID-19) compared to healthy pregnant women.

Methods: A retrospective case-control study conducted at the Al Yarmouk Teaching Hospital, in Baghdad, Iraq, involving 100 pregnant women, 50 with positive viral DNA for COVID-19 (case group), and 50 with negative results (control group); both groups were subjected to a thorough hematological evaluation.

Results: Among the main hematological variables analyzed, the platelet indices, namely the mean platelet volume (MPV) and the platelet distribution width (PDW), showed statistically significant differences (MPV: 10.87 ± 66.92 fL for the case group versus 9.84 ± 1.2 fL for the control group; PDW: 14.82 ± 3.18 fL for the case group versus 13.3 ± 2.16 fL for the controls). The criterion value of the receiver operating characteristic (ROC) curve for PDW at a cutoff point of > 11.8 fL showed a weak diagnostic marker, while the MPV at a cutoff value of > 10.17 fL showed a good diagnostic marker.

Conclusion: The MPV and PDW are significantly affected by the this viral infection, even in asymptomatic confirmed cases, and we recommend that both parameters be included in the diagnostic panel of this infection.

Objetivo: Descrever as alterações hematológicas, em particular os índices plaquetários em gestantes com doença coronavírus 2019 (COVID-19) em comparação com gestantes saudáveis. MéTODOS: Estudo caso-controle retrospectivo realizado no Hospital Universitário Al Yarmouk, em Bagdá, Iraque envolvendo 100 gestantes, 50 com DNA viral positivo para COVID-19 (grupo caso) e 50 com resultados negativos (grupo controle); ambos os grupos foram submetidos a uma avaliação hematológica completa.

Resultados: Entre as principais variáveis hematológicas analisadas, os índices plaquetários, nomeadamente o volume plaquetário médio (VPM) e a largura de distribuição plaquetária (PDW), apresentaram diferenças estatisticamente significativas (VPM: 10,87 ± 66,92 fL para o grupo caso versus 9,84 ± 1.2 fL para o o grupo controle; PDW: 14,82 ± 3,18 fL para o grupo caso versus 13,3 ± 2,16 fL para os controles). O valor de critério da curva de característica de operação do receptor (ROC) para PDW em um ponto de corte de> 11,8 fL mostrou um marcador diagnóstico fraco, enquanto o do VPM em um valor de corte de> 10,17 fL mostrou um bom marcador de diagnóstico. CONCLUSãO: O MPV e PDW são significativamente afetados por esta infecção viral, mesmo em casos confirmados assintomáticos, e recomendamos que ambos os parâmetros sejam incluídos no painel de diagnóstico desta infecção.

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Conflict of interest statement

The authors have no conflict of interests to declare.

Figures

Fig. 1
Fig. 1
Flowchart of study sample.
Fig. 2
Fig. 2
Receiver operating characteristic (ROC) curve for platelet distribution width (PDW).
Fig. 3
Fig. 3
Receiver operating characteristic (ROC) Curve for mean platelet volume (MPV).
See this image and copyright information in PMC

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References

    1. Humanitas COVID-19 Task Force . Lodigiani C, Iapichino G, Carenzo L, Cecconi M, Ferrazzi P, Sebastian T. Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy. Thromb Res. 2020;191:9–14. doi: 10.1016/j.thromres.2020.04.024. - DOI - PMC - PubMed
    1. PROTECT Investigators for the Canadian Critical Care Trials Group and the Australian and New Zealand Intensive Care Society Clinical Trials Group . Cook D, Meade M, Guyatt G, Walter S, Heels Ansdell D, Heels-Ansdell Ansdell D, Warkentin T E. Dalteparin versus unfractionated heparin in critically ill patients. N Engl J Med. 2011;364(14):1305–1314. doi: 10.1056/NEJMoa1014475. - DOI - PubMed
    1. Avnon L S, Munteanu D, Smoliakov A, Jotkowitz A, Barski L. Thromboembolic events in patients with severe pandemic influenza A/H1N1. Eur J Intern Med. 2015;26(08):596–598. doi: 10.1016/j.ejim.2015.08.017. - DOI - PubMed
    1. Koupenova M, Freedman J E. Platelets and immunity: going viral. Arterioscler Thromb Vasc Biol. 2020;40(07):1605–1607. doi: 10.1161/ATVBAHA.120.314620. - DOI - PMC - PubMed
    1. Al-Samkari H, Karp Leaf R S, Dzik W H, Carlson J C, Fogerty A E, Waheed A. COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection. Blood. 2020;136(04):489–500. doi: 10.1182/blood.2020006520. - DOI - PMC - PubMed

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