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. 2021;10(4):313-319.
doi: 10.14283/jfa.2021.15.

Healthy Aging Biomarkers: The INSPIRE's Contribution

I Ader  1 , L Pénicaud, S Andrieu, J R Beard, N Davezac, C Dray, N Fazilleau, P Gourdy, S Guyonnet, R Liblau, A Parini, P Payoux, C Rampon, I Raymond-Letron, Y Rolland, P de Souto Barreto, P Valet, N Vergnolle, F Sierra, B Vellas, L Casteilla
Affiliations

Healthy Aging Biomarkers: The INSPIRE's Contribution

I Ader et al. J Frailty Aging. 2021.

Abstract

The find solutions for optimizing healthy aging and increase health span is one of the main challenges for our society. A novel healthcare model based on integration and a shift on research and care towards the maintenance of optimal functional levels are now seen as priorities by the WHO. To address this issue, an integrative global strategy mixing longitudinal and experimental cohorts with an innovative transverse understanding of physiological functioning is missing. While the current approach to the biology of aging is mainly focused on parenchymal cells, we propose that age-related loss of function is largely determined by three elements which constitute the general ground supporting the different specific parenchyma: i.e. the stroma, the immune system and metabolism. Such strategy that is implemented in INSPIRE projects can strongly help to find a composite biomarker capable of predicting changes in capacity across the life course with thresholds signalling frailty and care dependence.

Keywords: Biomarkers; dependence; frailty; healthy aging.

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Conflict of interest statement

All authors of the paper “The INSPIRE research initiative: a program for GeroScience and healthy aging research going from animal models to humans and the healthcare system” declare no Conflicts of Interest related to this manuscript.

Figures

Figure 1
Figure 1
Markers for 4 P Healthy aging Medicine
Figure 2
Figure 2
INSPIRE shared bio-resources
Figure 3
Figure 3
INSPIRE strategy
See this image and copyright information in PMC

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