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. 2022 May 30;74(10):1855-1858.
doi: 10.1093/cid/ciab835.

Total and Unbound Doravirine Concentrations and Viral Suppression in CSF

Juan Tiraboschi  1 , Sofia Scévola  1 , Sujan Dilly Penchala  2 , Elisabeth Challenger  2 , Laura Else  2 , Paula Prieto  1 , Maria Saumoy  1 , Arkaitz Imaz  1 , Ana Silva-Klug  1 , Jordi Niubó  3 , Irene Soriano  1 , Saye Khoo  2 , Raul Rigo-Bonin  4 , Daniel Podzamczer  1
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Total and Unbound Doravirine Concentrations and Viral Suppression in CSF

Juan Tiraboschi et al. Clin Infect Dis. .

Abstract

We determined total and unbound concentrations of doravirine (DOR) in cerebrospinal fluid and blood plasma. Total and unbound DOR concentrations in cerebrospinal fluid exceeded the half-maximal effective concentration against wild-type virus (5.1 ng/mL) in all patients, suggesting that DOR may contribute to inhibit viral replication in this compartment.

Keywords: CNS; CSF; Doravirine; HIV; concentrations; unbound.

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