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. 2022 Sep;5(9):e1554.
doi: 10.1002/cnr2.1554. Epub 2021 Sep 22.

Impact of surgery associated with radiotherapy on the prognosis of breast cancer - Guinea Breast Cancer Cohort Study

Bangaly Traore  1 , Mamady Keita  1 , Abdoulaye Toure  2 , Ibrahima Camara  2 , Assiatou Barry  1 , Moussa Koulibaly  3
Affiliations

Impact of surgery associated with radiotherapy on the prognosis of breast cancer - Guinea Breast Cancer Cohort Study

Bangaly Traore et al. Cancer Rep (Hoboken). 2022 Sep.

Abstract

Background: In a country where radiotherapy (RT) is not available, advocacy based on the relevance of surgery + adjuvant RT in locoregional control and survival is needed.

Aim: To evaluate the impact of surgery with RT on local control and survival compared to surgery alone in breast cancer (BC).

Methods and results: Between 2007 and 2016, 210 patients with BC were retrospectively reviewed, of which 90 patients underwent surgery with RT (group 1) and 120 patients' surgery (group 2). There were several treatment combinations, including surgery combined with neoadjuvant chemotherapy [ACT], RT, and ACT. The results showed 88 (41.9%) cases of relapse, including 31 (34.4%) (group 1) and 57 (47.5%) (group 2) (p = .046). Recurrence occurred after a mean time of 1.5 years in group 1 versus 0.66 years in group 2 (p = .006). The 5-year overall and BC-specific survivals were 49.5% and 62.5%, respectively. The 5-year survival was 60.0% (group 1) and 40.0% (group 2) (p < .05). In a multivariate analysis by Cox model, we found that the risk of death was 1.90 81 (95% CI [1.17 09-3.0701]) higher in group 2 (p = .009022), 1.69 85 (95% CI 1.00087-23.86157) in obese patients and decreased by 0.21 (95% CI [0.129-0.368]) in patients who did not relapse (p < .001).

Conclusion: In this study with several combination therapies, we cannot confirm that RT improves mainly locally advanced BC prognosis regardless of systemic treatment. However, we found that the risk of death correlated with the absence of RT, overweight, and risk of recurrence. Consideration of combinations of locoregional and systemic therapies, clinicopathological and biological data could improve the relevance of these results with a large sample size.

Keywords: breast cancer; radiotherapy; recurrence; surgery; survival.

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Conflict of interest statement

T B, K M, T A, C I, B A, and K M received no funding for this publication. The authors have stated explicitly that there are no conflicts of interest in connection with this article.

Figures

FIGURE 1
FIGURE 1
Overall and breast cancer‐specific survivals of patients treated by surgery with/without radiotherapy–breast cancer cohort Guinea
FIGURE 2
FIGURE 2
Comparative survival curve of breast cancers according to the clinical stage–Breast cancer cohort Guinea
FIGURE 3
FIGURE 3
Comparative survival curve of breast cancers treated with and without radiotherapy–breast cancer cohort Guinea
FIGURE 4
FIGURE 4
Comparative survival curve according to breast cancer relapse–breast cancer cohort Guinea
See this image and copyright information in PMC

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