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Review
. 2022 Apr;24(2):181-197.
doi: 10.1007/s11307-021-01652-7. Epub 2021 Sep 22.

ImmunoPET: harnessing antibodies for imaging immune cells

Anna M Wu  1   2 , Neeta Pandit-Taskar  3   4   5
Affiliations
Review

ImmunoPET: harnessing antibodies for imaging immune cells

Anna M Wu et al. Mol Imaging Biol. 2022 Apr.

Abstract

Dramatic, but uneven, progress in the development of immunotherapies for cancer has created a need for better diagnostic technologies including innovative non-invasive imaging approaches. This review discusses challenges and opportunities for molecular imaging in immuno-oncology and focuses on the unique role that antibodies can fill. ImmunoPET has been implemented for detection of immune cell subsets, activation and inhibitory biomarkers, tracking adoptively transferred cellular therapeutics, and many additional applications in preclinical models. Parallel progress in radionuclide availability and infrastructure supporting biopharmaceutical manufacturing has accelerated clinical translation. ImmunoPET is poised to provide key information on prognosis, patient selection, and monitoring immune responses to therapy in cancer and beyond.

Keywords: Antibodies; CD8; Cancer; ImmunoPET; Immunotherapy; T cells.

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