Reply to: A finding of sex similarities rather than differences in COVID-19 outcomes

Takehiro Takahashi¹, Mallory K Ellingson², Patrick Wong³, Benjamin Israelow^{3

4}, Carolina Lucas³, Jon Klein³, Julio Silva³, Tianyang Mao³, Ji Eun Oh³, Maria Tokuyama³, Peiwen Lu³, Arvind Venkataraman³, Annsea Park³, Feimei Liu^{3

5}, Amit Meir⁶, Jonathan Sun⁷, Eric Y Wang³, Arnau Casanovas-Massana⁸, Anne L Wyllie⁸, Chantal B F Vogels⁸, Rebecca Earnest⁸, Sarah Lapidus⁸, Isabel M Ott^{8

9}, Adam J Moore⁸, Albert Shaw⁴, John B Fournier⁴, Camila D Odio⁴, Shelli Farhadian⁴, Charles Dela Cruz¹⁰, Nathan D Grubaugh⁸, Wade L Schulz^{11

12}, Aaron M Ring³, Albert I Ko⁸, Saad B Omer^{13

14

15

16}, Akiko Iwasaki^{17

18}

Affiliations

¹ Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. takehiro.takahashi@yale.edu.
² Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA. mallory.ellingson@yale.edu.
³ Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
⁴ Department of Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT, USA.
⁵ Department of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, CT, USA.
⁶ Boyer Center for Molecular Medicine, Department of Microbial Pathogenesis, Yale University, New Haven, CT, USA.
⁷ Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA.
⁸ Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.
⁹ Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA.
¹⁰ Department of Medicine, Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, CT, USA.
¹¹ Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.
¹² Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, CT, USA.
¹³ Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA. saad.omer@yale.edu.
¹⁴ Department of Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT, USA. saad.omer@yale.edu.
¹⁵ Yale Institute for Global Health, Yale University, New Haven, CT, USA. saad.omer@yale.edu.
¹⁶ Yale School of Nursing, Yale University, Orange, CT, USA. saad.omer@yale.edu.
¹⁷ Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. akiko.iwasaki@yale.edu.
¹⁸ Howard Hughes Medical Institute, Chevy Chase, MD, USA. akiko.iwasaki@yale.edu.

PMID: 34552250
DOI: 10.1038/s41586-021-03645-6

Comment

Reply to: A finding of sex similarities rather than differences in COVID-19 outcomes

Takehiro Takahashi et al. Nature. 2021 Sep.

. 2021 Sep;597(7877):E10-E11.

doi: 10.1038/s41586-021-03645-6.

Authors

Affiliations

¹ Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. takehiro.takahashi@yale.edu.
² Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA. mallory.ellingson@yale.edu.
³ Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
⁴ Department of Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT, USA.
⁵ Department of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, CT, USA.
⁶ Boyer Center for Molecular Medicine, Department of Microbial Pathogenesis, Yale University, New Haven, CT, USA.
⁷ Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA.
⁸ Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.
⁹ Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA.
¹⁰ Department of Medicine, Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, CT, USA.
¹¹ Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.
¹² Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, CT, USA.
¹³ Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA. saad.omer@yale.edu.
¹⁴ Department of Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT, USA. saad.omer@yale.edu.
¹⁵ Yale Institute for Global Health, Yale University, New Haven, CT, USA. saad.omer@yale.edu.
¹⁶ Yale School of Nursing, Yale University, Orange, CT, USA. saad.omer@yale.edu.
¹⁷ Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. akiko.iwasaki@yale.edu.
¹⁸ Howard Hughes Medical Institute, Chevy Chase, MD, USA. akiko.iwasaki@yale.edu.

PMID: 34552250
DOI: 10.1038/s41586-021-03645-6

No abstract available

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Comment on

A finding of sex similarities rather than differences in COVID-19 outcomes.
Shattuck-Heidorn H, Danielsen AC, Gompers A, Bruch JD, Zhao H, Boulicault M, Marsella J, Richardson SS. Shattuck-Heidorn H, et al. Nature. 2021 Sep;597(7877):E7-E9. doi: 10.1038/s41586-021-03644-7. Epub 2021 Sep 22. Nature. 2021. PMID: 34552251 No abstract available.

References

1. Shattuck-Heidorn, H. et al. A finding of sex similarities rather than differences in COVID-19 outcomes. Nature https://doi.org/10.1038/s41586-021-03644-7 (2021).
1. Takahashi, T. et al. Sex differences in immune responses that underlie COVID-19 disease outcomes. Nature 588, 315–320 (2020). - DOI
1. Klein, S. L. & Flanagan, K. L. Sex differences in immune responses. Nat. Rev. Immunol. 16, 626–638 (2016). - DOI
1. Bunders, M. J. & Altfeld, M. Implications of sex differences in immunity for SARS-CoV-2 pathogenesis and design of therapeutic interventions. Immunity 53, 487–495 (2020). - DOI
1. Klein, S. L. et al. Biological sex impacts COVID-19 outcomes. PLoS Pathog. 16, e1008570 (2020). - DOI

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Reply to: A finding of sex similarities rather than differences in COVID-19 outcomes

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Reply to: A finding of sex similarities rather than differences in COVID-19 outcomes

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